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diagnosis blood hemeonc product reactions activation algorithm anemia aplastic differential emergencies erythematous fever hemophagocytic hlh leukostasis lymphohistiocytosis lysis macrophage nikolsky
Erythematous Rashes - THE ALGORITHMIC APPROACH Characterized by diffuse redness of the skin due to capillary congestion, erythematous
erythematous rash ... may be having ... #Diagnosis #Dermatology ... #Erythematous #Rash ... Algorithm #Nikolsky #Febrile
Sweet Syndrome Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
Acute febrile ... - Rash: multiple ... Episcleritis Signs ... #diagnosis #dermatology ... #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
manifestation of MAS ... purpura to mucosal bleeding ... Petechial or purpuric rash ... #Diagnosis #Management ... #Hematology #Rheumatology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... Aplastic #Anemia #oncology ... #hematology #diagnosis ... #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
: - Neuro: AMS ... WBC >100k, + lab signs ... Treatment: - If febrile ... TLS #diagnosis #management ... #hematology
Summary of Oncologic Emergencies Neutropenic fever: - Fever + ANC < 500 → start cefepime ± vancomycin (if
work-up - If febrile ... rising > 500 → may ... ): - Hematologic ... Simultaneous clotting and bleeding ... - CRS: fever, rash
Blood Transfusion Reactions Immune Mediated: • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
Mediated: • Febrile ... maculopapular rash ... coagulopathy & ↑bleeding ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary Type and screen - determines blood type and detects in recipient
Mediated: - Febrile ... maculopapular rash ... coagulopathy & ↑bleeding ... Transfusions #diagnosis #management ... #hematology #reactions
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
recognition and management ... consideration in febrile ... (often termed MAS-HLH ... Presentation • Common Signs ... #Hematology #HemeOnc
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