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oncology management mds myelodysplastic syndrome workup activation algorithm anticoagulation calculators cancer causes cell chronic cll differential factors hasbled leukemia lymphocytic
Bleeding risk calculators - HAS-BLED (atrial fibrillation) and IMPROVE (VTE prophylaxis for inpatients) Important notes: • No
(VTE prophylaxis ... validated for VTE ... treatment, only ... Anticoagulation #Factors #Hematology ... #Diagnosis
Aplastic Anemia - Illness Script Signs and symptoms: • Recurrent infections from neutropenia • Mucosal bleeding from
Aplastic Anemia ... neutropenia • Mucosal bleeding ... Treatment: • Consider ... #Anemia #diagnosis ... #hematology
Myelodysplastic Syndrome (MD) - Diagnosis and Management Summary myelo (marrow) -dys- (abnormal) -plastic (shape) = funny-shaped cells
dys- (abnormal) -plastic ... cytopenias (usually anemia ... Hypomethylating agents to improve ... #Management #treatment ... #hematology #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Aplastic Anemia ... • Aplastic anemia ... anemia Treatment ... : • Improve the ... #hematology #diagnosis
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
unusual bruising or bleeding ... are caused by bleeding ... • Aplastic Anemia ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
purpura to mucosal bleeding ... with leukopenia, anemia ... Treatment: • Corticosteroids ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... • Neutropenia, anemia ... Pure red cell aplasia ... microglobulin Treatment ... workup #oncology #hematology
Causes of Neutropenia - Differential Diagnosis Neonate: - Infection - by far the most common cause -
- Differential Diagnosis ... hypertension and/or drug treatment ... Megaloblastic anemia-rare ... white blood cell aplasia ... #causes #hematology
Myelodysplastic syndromes current treatment algorithm 2018. From Blood Cancer Journal, Published 24 May 2018 Myelodysplastic syndromes (MDS) are
syndromes current treatment ... median age at diagnosis ... disease tolerate anemia ... an infection or bleeding ... #algorithm #hematology
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
Diagnosis? ... • No CRAB - no anemia ... Bone marrow Treatment ... associated with improved ... #Workup #Hematology
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