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anticoagulation pharmacology algorithm oncology oral cancer dvt malignancy noac thromboembolism venous bridging causes chemotherapy coagulation cyp3a4 dabigatran diagnosis dic direct
Oral anticoagulant dosing and bridging for VTE - Dr. Joseph Shatzel @Clotmaster #VTE #DOAC #Bridging #Dosing #Oral
Oral anticoagulant ... and bridging for VTE ... #DOAC #Bridging ... Anticoagulation #Dabigatran #Apixaban ... #Pharmacology #Hematology
NOAC / DOAC Pharmacology and Prescribing Cheat Sheet Novel (or Direct) Oral Anti-Coagulants • Rivaroxaban • Apixaban
NOAC / DOAC Pharmacology ... Rivaroxaban • Apixaban ... #Prescribing #hematology ... #management #Direct ... #Oral #AntiCoagulant
Patient risk stratification algorithm for the treatment of cancer-associated thrombosis. Currently, edoxaban and rivaroxaban are the only
algorithm for the treatment ... body mass index; VTE ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
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 Treatment algorithm for VTE in Malignancy (A) Suggested treatment algorithm for symptomatic and incidental DVT or PE
for VTE in Malignancy ... DOAC, direct oral ... #DOAC #VTE #Malignancy ... Anticoagulation #Management ... #Hematology #Oncology
DOAC Reversal Emergency surgery or urgent procedure Stop anticoagulant treatment; volume resuscitation and transfusion as needed Antidotes: • Apixaban,
procedure Stop anticoagulant ... treatment; volume ... Antidotes: • Apixaban ... #Oral #anticoagulant ... #hematology #management
Perioperative Management of DOACs Problem: ✖ Each year approximately 250,000 patients on chronic anticoagulation in North America
Perioperative Management ... interruption per treatment ... and procedural bleeding ... with a very low bleeding ... inhibitor) • Apixaban
Venous Thromboembolism Treatment Algorithm Branch points: Active bleeding? Active malignancy? Provoked? - Dr. Joseph Shatzel @Clotmaster #Management #VTE #DVT
Thromboembolism Treatment ... points: Active bleeding ... @Clotmaster #Management ... #VTE #DVT #Algorithm ... #Hematology #Anticoagulation
(DOAC interactions) Cancer-treatment specific inducers (↑) and inhibitors (↓) of cytochrome p450 CYP3A4 and P-glycoprotein. DOACs are substrates
) Cancer-treatment ... thereby leading ... rivaroxaban, and apixaban ... Rivaroxaban and apixaban ... Chemotherapy #Oncology #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Findings: • Bleeding ... Reduction of pro/anticoagulants ... Treatment: ... diagnosis #causes #treatment ... #management #hematology
Longterm Venous Thromboembolism Treatment Algorithm Treat for 3 months and reassess • Isolated distal DVT (without cancer)
Thromboembolism Treatment ... PE - High Bleeding ... therapy - Second VTE ... #Algorithm #management ... #hematology #anticoagulation
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