17 results
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... of Chronic Disease ... 80-100 fL) • Bleeding ... #MCV #Classification ... Algorithm #Causes #Hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • Anemia of Chronic ... • RBC Membrane Disorder ... #Classification ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
, Chronic disease ... Unstable hemoglobin disorders ... Cell Agglutinate: Cold ... , Paroxysmal cold ... differential #diagnosis #hematology
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
malignancies • Anemia ... hemorrhage) • Chronic ... inflammatory disorders ... Myelodysplastic syndrome ... Diagnosis #Causes #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- History of bleeding ... epistaxis, gingival bleeding ... practices that could ... changes), high MCV anemia ... Causes #Workup #hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
) - HELLP syndrome ... (e.g. primary cold ... lymphoproliferative disorders ... differential #diagnosis #hematology ... #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... Agglutinin Syndrome ... • Symptoms of anemia ... • hemolytic anemia ... #hematology #diagnosis
Nail Disorders secondary to Systemic Diseases
Nail Fold Abnormality
 • SLE
 • Scleroderma
 • Dermatomyositis
Koilonychia - Spoon-shaped
Nail Disorders secondary ... Diseases Nail Fold ... Iron deficiency anemia ... discoloration) • Chronic ... • Nephrotic syndrome
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
Constitutional Syndromes ... ecchymoses, mucosal bleeding ... Constitutional Syndromes ... Anticonvulsants - Gold ... #oncology #hematology
Commonly Observed Laboratory Findings in Hepatic / Liver Failure
 - Elevated conjugated and unconjugated bilirubin -
Elevations of —100-fold ... hepatocytes; in chronic ... anemia; blood loss ... the hepatorenal syndrome ... LiverFailure #Hepatic #Hepatology