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diagnosis differential causes algorithm mcv morphology rbc aplastic bloodcell classification elevatedmcv key macrocytic macrocytosis management mds microscopy morphologic myelodysplastic neutropenia
Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Toxins • Aplastic Anemia ... • Myelodysplasia ... Nutritional deficiency ... : • B12/folate ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
RBC) Morphology Atlas ... Liver diseases, Myelodysplastic ... Liver diseases, Bleeding ... RBC #Morphology #Atlas ... #differential #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80-100 fL) • Bleeding ... (>100 fL) • B12 ... Deficiency • ... Hypothyroidism • Myelodysplasia ... Algorithm #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
• Dietary Deficiency ... - Low Serum B12 ... Dysplastic • Myelodysplastic ... and Folate Deficiency ... Algorithm #Causes #Hematology
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Megaloblastic: Vitamin B12 ... deficiency, Folate ... deficiency • ... Hypothyroidism, Myelodysplastic ... diagnosis #causes #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
RBC: Pyridoxine deficiency ... Macrocytic RBC: Vitamin B12 ... or Folate deficiency ... differential #diagnosis #hematology ... #microscopy #atlas
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Nutritional: vitamin B12 ... or folic acid deficiency ... treatments • Copper deficiency ... Syndromes #diagnosis #hematology ... #oncology
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
ecchymoses, mucosal bleeding ... , GATA2 deficiency ... , CTLA4 deficiency ... • Hypocellular myelodysplastic ... #oncology #hematology
Etiologies of Vitamin B12 Deficiency • Inadequate intake - Rare but seen in very strict vegans
Deficiency • Inadequate ... deficiency. ... pump blockers is leading ... autoantibodies (pernicious anemia ... differential #diagnosis #hematology
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