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diagnosis differential algorithm management intravascular atlas classification elevatedmcv extravascular hemolysis leukemia macrocytosis morphology product reactions workup aplastic approach bloodcell calculation
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Diagnosis Algorithm Blood ... Reticulocytes • Iron Deficiency ... • B12/Folate Deficiency ... Diagnosis #Algorithm #Causes ... #Hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... disease, McLeod blood ... Burr Cell RBC (Echinocyte ... Bite Cell RBC: G6PD ... differential #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... RBC) Morphology ... Liver diseases, Bleeding ... coagulopathy (DIC) #RBC ... #differential #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Algorithm Normal Blood ... Neutrophils - Low RBC ... RBCs in Rouleaux ... #Hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
the peripheral blood ... -> AML: Blast crises ... - infiltrates (anemia ... #Leukemia #Hematology ... #Oncology #Diagnosis
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... >13 • Iron Deficiency ... Blood Loss, Occult ... Malabsorption, Dietary Deficiency ... #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... , Intrinsic RBC ... defects (e.g. sickle cell ... anemia, G6PD deficiency ... Production #Index #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- History of bleeding ... plateletcount), peripheral blood ... changes), high MCV anemia ... not required in all ... #Workup #hematology
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Causes of Extravascular ... • Sickle cell ... elliptocytosis - RBC ... immune-complex hemolytic anemia ... #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... • Intrinsic RBC ... G6PD deficiency) ... differential #diagnosis #hematology ... #anemia
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