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diagnosis algorithm transaminitis causes hepatitis lfts aki chemistry druginduced elevated gap globulin hematology hepatocellular interpretation kidneyinjury nephrology patterns protein proteingap
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
Injury (DILI) - ... Hepatocellular: Viral infections ... HEV, EBV, CMV), ... dechallenge • Acute ... #Algorithm #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Acute Liver Injury ... • Infectious: HAV ... EBV, HSV, CMV, ... • Iatrogenic: DILI ... diagnosis #algorithm #hepatology
Elevated Transaminases / Transaminitis - Differential Diagnosis • Infectious: HAV, HCV, HEV, EBV, HSV, CMV •
Diagnosis • Infectious ... EBV, HSV, CMV ... Trauma: Shock liver ... • Iatrogenic: DILI ... Diagnosis #causes #hepatology
Causes of Acute Liver Injury - Differential Diagnosis Hepatocellular - Liver Parenchyma • Infectious: Hepatitis C, A,
Liver Injury - Differential ... C, A, E, B, D, EBV ... , CMV, HSV • Toxic ... #Injury #Differential ... #algorithm #hepatology
Hepatocellular Liver Injury - Differential Diagnosis Framework: Liver Injury → liver test abnormalities without evidence of liver
Injury - Differential ... Injury → liver ... Injury Differential ... Diagnosis: • Infections ... #Injury #Differential
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
hepatitis serologies, HCV ... Unconjugated Bili ... > 90% of Total Bili ... chemistry #diagnosis #differential ... #Hepatology #transaminitis
Causes of Acute Kidney Injury (AKI) - Differential Diagnosis Algorithm Acute Kidney Injury (AKI) - Acute increase
Kidney Injury (AKI ... ) - Differential ... AKI) - Acute increase ... • Drugs • HIV ... allopurinol, PPI) • Infections
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
> 20x normal - Acute ... 10-20x normal - Infection ... (EBV/CMV), Alcoholic ... #Injury #hepatology ... transaminitis #differential
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4) Work-up of an Elevated Globulin Gap: •
Include: • Viral infections ... (acute HIV, HBV ... Sarcoidosis) • Liver ... inflammation (acute ... Gap #ProteinGap #differential
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