10 results
Type I Hypersensitivity: Pathogenesis and clinical findings
Definition: Production of lgE Antibodies that bind to harmless allergens
Type I Hypersensitivity ... degranulation, leading ... Patient's immune system ... Anaphylaxis #TypeI ... #pathophysiology
Hypersensitivity Types and Their Mechanisms
Type I - lgE - Soluble antigen
 - Allergen-specific lgE antibodies bind
- Local and systemic ... cellular antigen, leading ... arthritis, and systemic ... #Classification ... #Pathophysiology
Summary table of types of hypersensitivity reactions. 
Type 1
 - Mediators: lgE
 - Antigen Form: Soluble
Mechanism of Action: Allergen-specific ... cell antigens, leading ... glomerulonephritis, Systemic ... #allergy #table ... #classification
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
site in lymphatic system ... with lymphatic system ... Lymphoproliferative #Disorders #Classification ... #pathophysiology ... #Hematology #Diagnosis
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... protein receptor type ... activin A receptor type ... dysfunction ... multifactorial mechanisms Hematologic
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... , leading to the ... disorder (e.g. systemic ... #classification ... #rheumatology #
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Encephalopathy, Cognitive Dysfunction ... Disease, PRES Pathophysiology ... inflammation, leading ... CNS #neurology #rheumatology
IGG-4 RELATED DISEASE

WHAT?
 • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
- Organ dysfunction ... PATHOPHYSIOLOGY ... progressive organ dysfunction ... • Pancreas: Type ... complement • Classification
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Skin Disease Classification ... Kikuchi disease • Type-I ... mild cognitive dysfunction ... vein thrombosis Hematologic
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
cytopenias and organ dysfunction ... of the immune system ... Types of HLH • ... Pathophysiology ... Diagnosis #Management #Hematology