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Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Hemolytic Anemia - Differential ... Antibody/DAT+ - Complement ... Hemolytic #Anemia #Differential
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... ThePeanutKidney #Complement ... Levels #C3 #C4 #differential
Infectious Risks in Asplenia and Deficiencies in Humoral Immunity and Complement - Venn Diagram Humoral Immunity: •
Humoral Immunity and Complement ... T and B cells Complement ... PrathitKulkarni #complement ... immunocompromised #infections #differential
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table • Thrombotic Thrombocytopenic Purpura (TTP)
Microangiopathy (TMA) - Differential ... HUS (aHUS) - Complement-mediated ... TMA #hematology #differential
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Syndromes and Mimics - Differential ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... Syndromes #Mimics #Differential
C5-C9 Deficiency - Pathogenesis and Clinical Findings Note: • Risk of invasive meningococcal disease is 1000-10000x higher
Pathogenesis and Clinical ... infections • Clinical ... is rare Normal complement ... response: The complement ... cell membranes -> Critical
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... Glomerulonephritis #Vasculitis #differential
Humoral Immunity - Pathogenesis and Clinical Findings Antigens (Ag) are produced from pathogens (bacteria, viruses, fungi, parasites)
Pathogenesis and Clinical ... activation • Complement ... tagged with C3 complement ... - Activate Complement ... proliferate and differentiate
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
Pathogenesis and Clinical ... dead tissue • Complement ... activation of complement
Differential diagnosis of schistocytes / fragmentation hemolysis: • Thrombotic microangiopathies (TMA) - TTP
Differential diagnosis ... (ST-HUS) - Complement-mediated ... #schistocytes #differential
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