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Infectious Risks in Asplenia and Deficiencies in Humoral Immunity and Complement - Venn Diagram Humoral Immunity: •
Infectious Risks ... Humoral Immunity and Complement ... T and B cells Complement ... immunocompromised #infections ... #differential #
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
Syndromes and Mimics - Differential ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement ... : Hantavirus infection ... Syndromes #Mimics #Differential
Causes of Hemolytic Anemia - Differential Diagnosis Inherited • Membrane • Internal - Hemoglobin
Hemolytic Anemia - Differential ... Antibody/DAT+ - Complement ... Internal - Infectious ... Hemolytic #Anemia #Differential
Effect of Selected Diseases on Complement Levels - C3, C4 • SLE C3 ↓ C4 ↓↓
Selected Diseases on Complement ... C3 ↓ C4 → • Infection ... ThePeanutKidney #Complement ... Levels #C3 #C4 #differential
Infections in Immunocompromised Patients - Differential Diagnosis Summary Innate Immunity: • Neutropenia • Phagocytic Deficiencies • Complement
Infections in Immunocompromised ... Patients - Differential ... Deficiencies • Complement ... Immunocompromised #Infections ... #differential #
Causes of Extravascular and Intravascular Hemolysis - Differential Diagnosis Algorithm Extravascular - Spleen and RES-mediated hemolysis -
Intravascular Hemolysis - Differential ... circulation - Infections ... perfringens - Complement-Mediated ... Extravascular #Differential
Causes of Fever in the Immunocompromised Host - Differential Diagnosis Algorithm Structural Defect - Asplenia/HypospIenism • Bacteremia/Septic
Immunocompromised Host - Differential ... • Perirectal Infection ... Periodontal Disease Complement ... Diarrhea • Giardia Infection ... ImmuneCompromised #Differential
Causes of ileitis beyond Crohn’s disease and infections include systemic disorders -spondyloarthropathies, vasculitides, ischemia, and amyloidosis
’s disease and infections ... helpful paper complements ... #GI #Ileitis #Differential
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
- Due to Viral infection ... Polyclonal - Viral Infection ... Check For: • Infections ... younger pts) Differential ... temperatures by fixing complement
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
anti-Smith Ab, low complements ... permanent alopecia Differential ... fibromyalgia) • Infections ... RNP antibodies, Complement
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