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diagnosis differential nephrology clinical algorithm management renal causes pathophysiology pocus ultrasound aki treatment acute rheumatology pharmacology hematology ckd table classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... staining): • Low Complement ... Idiopathic • Normal Complement ... • Limited to Kidney ... : Anti-GBM Glomerulonephritis
Comprehensive pathogenesis of IgA Nephropathy (i.e Berger’s Disease). IgA Nephropathy is the most common cause of
common cause of Glomerulonephritis ... Relationship of complement ... AcuteGlomerulonephritis #Glomerulonephritis ... NephriticSyndrome #Kidney
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Necrotizing glomerulonephritis ... , pauci-immune glomerulonephritis ... Polyarteritis Nodosa: - Kidneys ... Kidneys -> glomerulonephritis ... against MPO • Complement
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... Membranoproliferative #Glomerulonephritis
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... Hypocomplementemia #Low #Complement
Causes of Hematuria - Glomerular vs Non-glomerular == Glomerular == - Glomerulonephritis - Thin basement membrane disease ==
Glomerular == - Glomerulonephritis ... Non-glomerular == Kidney ... - Polycystic kidney
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement
Causes of Acute Kidney Injury ( AKI ) - Prerenal, Renal, and Postrenal PRE-RENAL Impaired perfusion: •
Causes of Acute Kidney ... occlusion RENAL Glomerulonephritis ... Diagnosis #Acute #Kidney
NSAID vs ACEI/ARB effects on the Kidneys Remember that NSAIDs and ACEI/ARB therapy have opposing effects on
effects on the Kidneys ... effects on the kidneys ... contribute to kidney ... patients with normal kidney ... used for their kidney
Acute Kidney Injury (AKI) - Differential Diagnosis Framework Prerenal: • Due to true volume loss or decreased
Acute Kidney Injury ... nephritis) • GN (glomerulonephritis ... Cellular debris • Kidney ... LouLectures #Acute #Kidney
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