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diagnosis symptoms signs differential management nephrology cardiology endocrinology pharmacology syndrome algorithm causes hematology infectiousdiseases msk complications pulmonary treatment lifecycle ophthalmology
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
Rapidly Progressive Glomerulonephritis ... three primary pathophysiologic ... staining): • Low Complement ... Idiopathic • Normal Complement ... Kidney: Anti-GBM Glomerulonephritis
Hypersensitivity Types and Their Mechanisms Type I - lgE - Soluble antigen - Allergen-specific lgE antibodies bind
antigen, leading to complement ... Complement activation ... Post-streptococcal glomerulonephritis ... Classification #Pathophysiology
Membranoproliferative Glomerulonephritis (MPGN) AKA: Mesangiocapillary GN • Active Urine Sediment (dysmorphic RBC, RBC casts, +/- proteinuria)
Membranoproliferative Glomerulonephritis ... staining (lg + complement ... MGPN • Complement ... of alternative complement ... Membranoproliferative #Glomerulonephritis
Complement Pathways - Classical Pathway - Lectin Pathway - Alternative Pathway #Complement #Pathway #hematology #pathophysiology
Complement Pathways ... Alternative Pathway #Complement ... Pathway #hematology #pathophysiology
Overview of the Complement System - Classical and Alternative Pathways by Dr.Grace Leo @gracie_leo #Complement #System #Classical #Alternative
Overview of the Complement ... gracie_leo #Complement ... Alternative #Pathways #Pathophysiology
Causes of Hypocomplementemia - CHAMPS Mnemonic C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis H - Heavy Chain deposition
Membranoproliferative glomerulonephritis ... Post/pauci immune glomerulonephritis ... Hypocomplementemia #Low #Complement
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
rapidly progressive glomerulonephritis ... anti-GBM) 10%: - Low Complement ... Vasculitis - Normal Complement
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Pathophysiology ... Complex Formation - Complement ... Vasculitis #HUV #Pathophysiology
Inflammatory Cascade: Pathogenesis and Clinical Findings Continued Innate Immunity • Phagocytosis: (main mechanism) neutrophils and macrophages engulf
dead tissue • Complement ... activation of complement ... #Inflammation #pathophysiology
Glomerular Diseases - Nephritic and Nephrotic Syndromes Nephritic syndrome: - Acute poststreptococcal glomerulonephritis - Rapidly progressive
poststreptococcal glomerulonephritis ... Rapidly progressive glomerulonephritis ... proliferative glomerulonephritis ... Membranoproliferative glomerulonephritis
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