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diagnosis differential causes management rheumatology treatment hematology dermatology pulmonary nephrology pediatrics gastroenterology peds endocrinology neurology cardiology workup hepatology ibd acute
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
staining): • Low Complement ... Idiopathic • Normal Complement ... involvement: Anti-GBM Disease ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Pulmonary Renal Syndromes and Mimics - Differential Diagnosis Framework Diffuse alveolar hemorrhage + rapidly progressive glomerulonephritis 90%: -
ANCA Associated Vasculitis ... - Anti-GBM Disease ... anti-GBM) 10%: - Low Complement ... - Normal Complement ... , Behcet's Disease
A System for Vasculitides #Diagnosis #IM #Rheum #Vasculitis #Small #Medium #Large #Vessel #Size #Classification #ANCA #Differential
A System for Vasculitides ... Diagnosis #IM #Rheum #Vasculitis ... #Differential #Algorithm
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
pain • Kawasaki Disease ... (Granulomatous disease ... atherosclerotic disease ... most important diseases ... against MPO • Complement
Small Vessel Vasculitides • Granulomatosis with polyangiitis - Granulomatous manifestations (e.g., nasal crusting, destructive sinusitis, pulmonary
Small Vessel Vasculitides ... Interstitial lung disease ... Cryoglobulinemic vasculitis ... syndrome • IgA vasculitis ... #vasculitis #differential
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of Vasculitis ... Vasculitis of ... - Kawasaki disease ... and infectious diseases ... - serum disease
Pathophysiology of Hypocomplementemic Urticarial Vasculitis C1q/anti-C1q antibiody -> Immune Complex Formation - Complement Pathway Activation (C3a and C5a)
Hypocomplementemic Urticarial Vasculitis ... Complex Formation - Complement ... Formation -> Vasculitis ... Hypocomplementemic #Urticarial #Vasculitis
ANCA-Associated Vasculitis A group of necrotizing, small-vessel vasculitis without immune complex deposition. Complement levels are normal due
ANCA-Associated Vasculitis ... , small-vessel vasculitis ... Complement levels ... PR3 Anti-GBM disease ... ANCA #Associated #Vasculitis
Polyarteritis Nodosa (PAN) - Vasculitis Management Algorithm - ACR/VF 2021 Guidelines • Severe Disease → Remission
Nodosa (PAN) - Vasculitis ... Management Algorithm ... Guidelines • Severe Disease ... • Non-Severe Disease ... ACR2021 #Guidelines #algorithm
Petechial/Purpuric Rashes- THE ALGORITHMIC APPROACH These rashes can be especially challenging and are associated with devastating differential
Purpuric Rashes- THE ALGORITHMIC ... ; however, an algorithmic ... purpura occurs in vasculitic ... diseases secondary ... disseminated gonococcal disease
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