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Diuretics sites of action on the nephron 1) Acetazolamide (carbonic anhydrase inhibitor) 2) Osmotic diuretics (e.g. mannitol) 3) Loop
Diuretics sites ... inhibitor) 2) Osmotic ... diuretics (e.g. ... mannitol) 3) Loop diuretic ... Thiazides-type diuretics
Nephron Pathophysiology - Diuretic Sites of Action Diuretics 1) Acetazolamide/canagliflozin 2) Osmotic agents (mannitol, urearetics) 3) Loop agents (eg, furosemide) 4)
Pathophysiology - Diuretic ... Sites of Action Diuretics ... canagliflozin 2) Osmotic ... Pathophysiology #Diuretics
Causes of Hypernatremia - Differential Diagnosis Inadequate water intake: • Lack of access to water Extrarenal hypotonic fluid
Causes of Hypernatremia ... concentrating defect: • Diuretics ... • Osmotic diuresis ... Differential #Diagnosis #Causes
Summary of Diuretic Agents Subclass, Drug, Mechanism of Action, Effects, Clinical Applications, Pharmacokinetics, Toxicities, Interaction CARBONIC ANHYDRASE
Summary of Diuretic ... empagliflozin LOOP DIURETICS ... • Triamterene OSMOTIC ... DIURETICS • Mannitol ... Tolvaptan #Diuretics
Treatment of hyperkalemia via kaliuresis step 1 = volume resuscitation if hypovolemic step 2 = consider fludrocortisone step
fludrocortisone step 3 = diuretic ... determine response to diuretic ... criticalcare #treatment #diuretics ... #diuresis #nephrology
Overview of effects of diuretics and hormones involved in fluid homeostasis. #diruetic #diuretics #aldosterone #ADH #ANP #BNP #thiazide
of effects of diuretics ... #diruetic #diuretics ... acetazolamide #diamox #osmotic
Diuretic Electrolyte Excretion Effects Diuresis, Na+, K+, Mg2+, Ca2+, Cl-, HCO3-, Uric Acid - Thiazide Type
Diuretic Electrolyte ... Excretion Effects Diuresis ... Anhydrase Inhibitor #diuretics
Causes of Hypokalemia Transcellular Shifts: - Alkalosis, Increased plasma insulin (treatment of diabetic ketoacidosis), ß-Adrenergic agonists, Hypokalemic
Causes of Hypokalemia ... thiazide-like diuretics ... Postobstructive diuresis ... , Osmotic diuresis ... #Hypokalemia #Causes
Diuretics - Pharmacology Thiazides diuretics: • Inhibit Na+ Cl- cotransporter in distal tubule • Chlorothiazide, Chlorthalidone, Indapamide,
Diuretics - Pharmacology ... Thiazides diuretics ... Methazolamide Osmotic ... diuretics: • ... loop #thiazide #classes
Hypomagnesemia - Etiologies by Mechanism Decreased GI Uptake - Poor dietary intake (particularly common in alcoholics)
Loop and thiazide diuretics ... Hypokalemia - Osmotic ... diuresis - ... Post-obstructive diuresis ... Classification #Causes
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