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differential hepatology rheumatology algorithm pbc primary systemic workup antibodies antinxp2 antinxp2dm ascites associations autoimmune causes cholangitis dermatology dermatomyositis diseases erythematosus
Systemic Sclerosis Associated Autoantibodies Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis Anti-centromere: Limited skin disease (~93-95%), Pulmonary
Sclerosis Associated Autoantibodies ... ulcers, Primary Biliary ... Cirrhosis Anti-RNA ... Systemic #Sclerosis #Autoantibodies ... #diagnosis #rheumatology
Primary Biliary Cirrhosis - Diagnosis Algorithm Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort Signs: Jaundice, Xanthelasmata, Hepatomegaly Associated history:
Primary Biliary ... Cirrhosis - Diagnosis ... quadrant discomfort Signs ... #Cirrhosis #Diagnosis ... #Algorithm #hepatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Autoantibodies and ... Anti-gp210 - Primary biliary ... cirrhosis (PBC) ... Associations #diseases #diagnosis ... #table #rheumatology
Portal Hypertension - Differential Diagnosis Portal Pressure = the pressure difference between the pressure in the portal
- Differential Diagnosis ... significant portal HTN Signs ... pregnancy • Primary biliary ... #Differential #Diagnosis ... #causes #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
Primary Biliary ... Cirrhosis (PBC) ... failure PBC Signs ... #Cirrhosis #PBC ... #workup #hepatology
Ascites - Diagnostic Approach and Differential Diagnosis The most common causes: cirrhosis, malignancy and heart failure. Approx
Ascites - Diagnostic ... dullness, puddle sign ... incisional). 3) Signs ... concentration (bowel or biliary ... #hepatology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Erythematosus - Diagnosis ... 69% - Malar rash ... #autoantibodies ... #signs #symptoms ... #differential #rheumatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential Diagnosis ... disease: > 2 • NASH ... hepatitis: < 1 • Cirrhosis ... #differential #diagnosis ... #algorithm #hepatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
without these autoantibodies ... (blue-purple) rash ... • Erythematous rash ... chest (in a V-sign ... shoulders (in a shawl sign
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
- Differential Diagnosis ... Symptoms: • Gottron rash ... papules and Gottron sign ... ) • Shawl sign ... Mechanic's hands Autoantibodies
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