10 results
Systemic Sclerosis Associated Autoantibodies
Anti-topoisomerase I (anti-Sc170): Diffuse skin disease, Pulmonary fibrosis
Anti-centromere: Limited skin disease (~93-95%), Pulmonary
skin disease, Pulmonary ... disease (~93-95%), Pulmonary ... hypertension, Digital ... III: Diffuse, Renal ... Autoantibodies #diagnosis #rheumatology
Renal involvement in 35% of mixed cryoglobulinemia vasculitis 
Associated with : 
 • Absence of skin
Renal involvement ... day - 49% • Hypertension ... TerrierBen #Renal ... Cryoglobulinemia #Vasculitis #Management ... #Rheumatology #
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Agents Regulating Renal ... irrigation • Management ... Torsemide) • Acute pulmonary ... Inhibitors of Renal ... #Diuretics #Renal
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Imaging: CXR- pulmonary ... Anaphylaxis, Acute Renal ... APML #diagnosis #management ... #hematology #oncology
Renal Replacement Therapy (RRT) - ICU One Pager Summary
Indications (AIEOU):
 • A: Acidosis (usually severe metabolic)
Renal Replacement ... Fluid Overload (pulmonary ... , uncontrolled hypertension ... CRRT (Continuous renal ... #Therapy #RRT #managment
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Scleroderma Renal ... Abrupt onset of hypertension ... of arteries Management ... #Crisis #rheumatology ... nephrology #diagnosis #management
Blood Transfusion Reactions

Immune Mediated:
 • Febrile Non-Hemolytic Transfusion Reaction (FNHTR): Most common immune reaction to transfusion.
, DIC, hypoTN, renal ... ↑bleeding • Hypotension ... Transfusion #diagnosis #management ... #hematology #reactions
Blood Product Transfusions One Pager Summary
Type and screen - determines blood type and detects in recipient
, DIC, hypoTN, renal ... bleeding - Hypotension ... Transfusions #diagnosis #management ... #hematology #reactions
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
, INC risk PE, Pulmonary ... cirrhosis: 3%-20% Renal ... Distal (Type I) renal ... Sjogrens #Syndrome #Rheumatology ... #Diagnosis #Management
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
lipothymia, thirst, hypotension ... filling +++ (risk of pulmonary ... syndrome #diagnosis #management ... timeline #treatment #rheumatology