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Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Others: • Lupus ... gastrointestinal, and/or central ... • Cogan Syndrome ... such as systemic lupus ... purpura: strong sign
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
, small-vessel vasculitis ... ulceration • Ocular ... (panuveitis, retinal ... vasculitis) • ... diagnosis #management #signs
Clinical Features of Systemic Lupus (SLE)
General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%)
Eye: Sjögrens (15%)
Skin
Butterfly rash, Vasculitis ... of hip (rare), Arthritis ... Demyelinating syndromes ... disease (30%): ... erythematosus #signs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Erythematous, macular ... ANCA-associated vasculitis ... APLA/LAC: • Renal ... artery or vein ... thrombosis • Pelvic vein
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
pulmonary and renal ... purpura: Strong sign ... Angiitis of the Central ... gastrointestinal, and/or central ... • Cogan syndrome
Facial Swelling - Differential Diagnosis Framework for Facial Edema

Infectious:
	• Dental abscess
	• Ludwig's angina
	• Vincent's angina
	• Cellulitis
	•
Adult-onset Still's disease ... Trauma: • Ocular ... internal jugular vein ... : • Morbihan disease ... Differential #Diagnosis #PhysicalExam
Hematuria - Differential Diagnosis Framework

Gross Hematuria: Red/Dark urine
 • 1ml blood/liter urine can induce color change
hematuria • Signs ... Diagnostic of GN or vasculitis ... of glomerular disease ... vein thrombosis ... vein between aorta
Rheumatoid Arthritis - Signs and Symptoms
 • Ocular: Keratoconjunctivitis sicca, Episcleritis, Scleritis, Scleromalacia perforans
 • Pulmonary:
Rheumatoid Arthritis ... - Signs and Symptoms ... • Ocular: Keratoconjunctivitis ... Vascular: Rheumatoid vasculitis ... Thrombocytosis, Felty's syndrome
Sweet Syndrome

Acute febrile neutrophilic dermatosis (Sweets Syndrome) is a skin condition characterized by fever and inflamed
with systemic disease ... Episcleritis Signs ... Headaches - A general ... Leukocytoclastic vasculitis ... - Lupus - Leukemia
Sjogren's Syndrome Overview

Epidemiology:
• F > M: 9:1
• 5-6th Decades (can be any age)

Autoimmune exocrinopathy multisystemic disease
gland) biopsy • Ocular ... Involvement: • Central ... ) • Cutaneous vasculitis ... : 2% Systemic Vasculitis ... Arthralgia and Arthritis