94 results
IDSA Treatment Recommendations for Cryptococcal Meningoencephalitis - Induction, Consolidation and Maintenance Therapy

Table 2. Antifungal Treatment Recommendations
Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... Recommendations for Cryptococcal ... management #meningitis #cryptococcus
Spectrum of activity for systemic antifungal agents
Antifungals: 5FC, flucytosine; AMB, amphotericin B; ANI, anidulafungin; CAS, caspofungin;
activity for systemic antifungal ... agents Antifungals ... Aspergillus fumigatus, Cryptococcus ... .2015.10.012 #Antifungal
Rare Invasive Yeasts - Species and Antifungal Therapy

Cryptococcus, 
Geotrichum, 
Kodamaea, 
(Pichia)ohmeri, 
Malassezia, 
Pseudozyma, 
Rhodotorula, 
Saccharomyces, 
Saprochaete
- Species and Antifungal ... Therapy Cryptococcus ... Invasive #Yeasts #Antifungal
Antifungal Polyenes - Amphoterecin B, Abelcet, Ambisome - Antibiotics Class Overview

Mechanism: binds ergosterol in membrane and
Antifungal Polyenes ... : Zygomycetes, Cryptococcal ... Overview #Polyenes #Antifungal
Antifungal Echinocandins  - Antibiotics Class Overview

Mechanism: Inhibit glucan synthesis in fungal cell wall by blocking
Antifungal Echinocandins ... lack activity vs Cryptococcus ... Echinocandins #Antifungal
Flutycosine - Antibiotics Class Overview
 - 
Mechanism: 5-FC interferes with DNA and protein synthesis.  Only
infections: Severe cryptococcal ... #Flutycosine #Antifungal
Fungal Biomarkers: Beta-D-Glucan and Aspergillus Galactomannan
Beta-D-Glucan:
 • Polysaccharide cell wall component of many fungi
 • Pathogens:
- Negative: Cryptococcus ... Paecilomyces, Cryptococcus ... of mold-active antifungals
Immune Reconstitution Inflammatory Syndrome - Overview of IRIS

What Is IRIS?
	• A state of hyperinflammatory response that
cavitation • Cryptococcus ... patient has known cryptococcal ... for most OI • Cryptococcal ... -6 weeks after antifungal
Cryptococcal meningitis on T2 MRI
30 M from sub-Saharan Africa presents w/ progressive Headache x1 mo, +neck
Cryptococcal meningitis ... Cryptococcal meningitis ... initiation of antifungal ... initiation of antifungal ... IUIDfellowship #Cryptococcal
Important Fungal Stains
Mycology Lab:
 • Calcofluor white - Fluorochrome that binds glucans and chitin in fungal
polysaccharide capsule of Cryptococcus ... detection for cryptococcal ... mucopolysaccharide capsule of Cryptococcus ... cell walls of Cyptococcus