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Causes of Neutropenia with Pancytopenia - Differential Diagnosis Algorithm Sequestration: • Splenomegaly Marrow Infiltration: • Hematologic and non-hematologic
Pancytopenia - Differential ... malignancies • Infection ... Myelofibrosis Stem cell damage ... #Neutropenia #Differential
Causes of Rhabdomyolysis - Differential Diagnosis • Drugs & Toxins (Statins, alcohol, cocaine) • Direct Muscle
Rhabdomyolysis - Differential ... Direct Muscle Damage ... immobilization) • Infections ... Rhabdomyolysis #Differential
Causes of Thrombocytopenia - Differential Diagnosis Algorithm Decreased Megakaryopoiesis • Aplastic Anemia • Toxic Damage (e.g.
Thrombocytopenia - Differential ... Anemia • Toxic Damage ... Vasculitis • Infection ... Thrombocytopenia #Differential
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Thrombocytosis - Differential ... Myelofibrosis Infectious ... disease Tissue Damage ... Thrombocytosis #Differential
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Platelet Count - Differential ... TPO, TPO-RA • Infections ... : Chronic infections ... • Tissue damage ... Thrombocytosis #Platelets #Differential
Classification of Jaundice Unconjugated hyperbilirubinemia (predominantly indirect bilirubin) • Increased bilirubin production (eg, hemolytic anemias, hemolytic reactions,
and hepatocyte damage ... Hepatocellular damage ... eg, spirochetal infections ... , infectious mononucleosis ... #unconjugated #differential
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... SLE) - Viral infections ... APLS • Acute Infectious ... Scurvy - Actinic damage ... Vasculopathy #Purpura #Differential
Causes of Secondary Amenorrhea - Differential Diagnosis Algorithm Absence of menses for more than 3 cycles or
Secondary Amenorrhea - Differential ... Hypothalamic-Pituitary Stalk Damage ... Radiation • Infection ... Secondary #Amenorrhea #Differential
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... processes • Tissue damage ... overlook severe infections ... superior indicator of infection ... #Bandemia #differential
Leg Pain - Differential Diagnosis Framework Bone/Joint Causes of Leg Pain: • Fracture • Arthritis • Gout/pseudogout
Leg Pain - Differential ... Leg Pain: • Infection ... entrapment • Infections ... causing nerve damage ... #Leg #pain #differential
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