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hematology oncology treatment causes differential hemophagocytic hlh infectiousdiseases leukemia lymphohistiocytosis summary american arthritis cardiology chagas chronic cll erythematosus hemeonc lupus
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... (SLE) General: Fever ... pain (20%) Renal disease ... (75%): Anemia ( ... #rheumatology
Oroya Fever Hematologic disease caused by Bartonella bacilliformis Restricted to the Andes highlands of Peru & Ecuador B. bacilliformis:
disease caused ... Lutzomyia verrucarum Clinical ... severe hemolytic anemia ... Nodular → Mular DIAGNOSIS ... #diagnosis #management
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Viral Infection Clinical ... Immunoglobulin M (IgM) • Blood ... sensitize red blood ... Symptoms: High fevers ... #hematology #diagnosis
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
Clinical Presentation ... : • Fever • Fatigue ... recurrent infections/fevers ... result from low blood ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Phagocytosis of blood ... : fever +++, hepatosplenomegaly ... inhibitors under evaluation ... #management #treatment ... #summary #rheumatology
Bandemia Overview Normal: < 1% Clinically significant: > 10% Band neutrophils are slightly less mature than segmented neutrophils and
Normal: < 1% Clinically ... of peripheral blood ... • Autoimmune diseases ... tachycardia or fever ... count on initial evaluation
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
is the main clinical ... with leukopenia, anemia ... Activation #Syndrome #Diagnosis ... #Management #Hematology ... #Rheumatology
Renal Cell Carcinoma (RCC) - Diagnosis and Management Summary Clinical features - Classic triad (flank pain, hematuria,
and Management ... Summary Clinical ... Anemia (common) ... night sweats, fever ... with contrast Evaluation
Septic Arthritis - Diagnosis and Management Summary Clinical Exam: hot, swollen, pain with passive AND active ROM
and Management ... active ROM +/- fever ... necrosis, Lyme disease ... count, and crystal evaluation ... MH/CCF/CWRU EM
Lung Abscess - Diagnosis and Management Summary Lung Abscess Etiology: • Necrosis of lung parenchyma by a
Lung Abscess - Clinical ... : • 80% have fever ... Leukocytosis, anemia ... • Sputum/Blood ... Intervention: - Fevers
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