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differential causes deficiency algorithm gastroenterology nutrition hematology workup abdominal b12 cobalamin diarrhea fe ferritin gastrointestinal hospitalization management pain pathophysiology pseudoanemia
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... with anemia, diagnose ... inflammation or chronic ... tests Test for celiac ... disease with serology
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Elite athletes • Chronic ... Loss (without anaemia ... ): GI cancers, Donations ... Bleeding, Edema, Celiac ... #differential #diagnosis
Iron Deficiency Anemia - Differential Diagnosis Algorithm Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR • Blood loss:
Anemia - Differential ... Diagnosis Algorithm ... • Blood loss: GI ... - Structural: Celiac ... disease, Tropical
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Drugs, H pylori, Celiac ... Inflammation: IBD, Chronic ... disease (↑ hepcidin ... #differential #diagnosis ... #anemia #nutrition
Causes of Iron Deficiency - Differential Diagnosis Algorithm • Blood loss: GI (cancer, ulcer, IBD), GU
- Differential Diagnosis ... • Blood loss: GI ... kidney disease, ... of absorption): Celiac ... disease, Bypass
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
- Differential Diagnosis ... disorders • Celiac ... disease Tissue ... malignancy • Iron ... deficiency anemia
Chronic Abdominal Pain Causes - Differential Diagnosis Framework Many patients with chronic abdominal pain have had prior
- Differential Diagnosis ... have had prior evaluations ... bowel syndrome • Celiac ... ischemia • GI ... poisoning • Celiac
Chronic Diarrhea - Workup Osmotic: • Consider food diary and trial avoiding certain foods or meds, Consider
Chronic Diarrhea ... certain foods or meds ... Consider testing for celiac ... disease Inflammatory ... differential #testing #evaluation
Celiac Disease - Clinical Manifestations Gastrointestinal Manifestations: • Diarrhea, Loose stools, Dyspepsia, Flatulence, Chronic abdominal pain,
Celiac Disease - ... , Hepatitis • Iron-deficiency ... anaemia • Arthralgia ... #Disease #signs ... #symptoms #diagnosis
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
skin pallor • GI ... related to IBD, celiac ... disease, other ... total body stores Evaluation ... symptoms • P/E - GI
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