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diagnosis differential hematology algorithm cobalamin iron nutrition classification low mcv vitamin alkaline alp approach gastroenterology gastrointestinal hepatology hyophosphatasia management mds
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
Causes of Vitamin ... B12 Deficiency ... Intestine: SIBO, Celiac ... disease, IBD, Lymphoma ... Stomach: Pernicious anemia
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... of Chronic Disease ... of Chronic Disease ... (>100 fL) • B12 ... Diagnosis #Algorithm #Causes
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... Autoimmune - Pernicious anaemia ... , coeliac disease
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
of chronic kidney ... disease, Acute ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... differential #diagnosis #causes
Gastrointestinal Evaluation of Iron Deficiency Anemia In patients with anemia, diagnose iron deficiency if: • Ferritin <
Gastrointestinal Evaluation ... inflammation or chronic ... tests Test for celiac ... disease with serology ... #Evaluation #workup
Causes of Iron Deficiency • Inadequate Intake: Vegetarian/vegan diet, Malnutrition • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Loss (without anaemia ... Bleeding, Edema, Celiac ... ) #Iron #Deficiency
Causes of Iron Deficiency • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... Inflammation: IBD, Chronic ... disease (↑ hepcidin ... #diagnosis #anemia
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
RBCs on Smear • Chronic ... • B12/Folate ... Deficiency • Aplastic ... of Chronic Disease ... Diagnosis #Algorithm #Causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation
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