14 results
Causes of Vitamin B12 Deficiency - Cobalamin
Decreased Intake
Pancreas: Insufficiency
Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
B12 Deficiency ... Intestine: SIBO, Celiac ... disease, IBD, Lymphoma ... Stomach: Pernicious anemia ... #differential #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... of Chronic Disease ... of Chronic Disease ... (>100 fL) • B12
Causes of Low Vitamin B12 Levels
Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people
Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... , coeliac disease ... low #cobalamin #differential
Diagnostic Framework for Anemia (Morphological Approach - MCV)
Low MCV - <80fL - "Microcytic"
 • Iron deficiency
disease, Acute ... Megaloblastic: Vitamin B12 ... Alcohol use, Liver disease ... morphologic #mcv #differential ... #diagnosis #causes
Causes of Iron Deficiency
 • Inadequate Intake: Vegetarian/vegan diet, Malnutrition
 • Increased Body Needs: Infants/preschoolers, Pregnancy,
Causes of Iron Deficiency ... Elite athletes • Chronic ... Loss (without anaemia ... Bleeding, Edema, Celiac ... #differential #
Causes of Thrombocytosis - Differential Diagnosis Algorithm
Spurious:
 • Artifact (redo CBC)
Autonomous:
 • Essential thrombocytosis
 • Polycythemia
- Differential ... disorders • Celiac ... disease Tissue ... malignancy • Iron deficiency ... anemia #Thrombocytosis
Overall Approach to Anemia - Differential Diagnosis Algorithm

Blood Loss
 • Acute Bleed - Normocytic / Normochromic
- Differential ... RBCs on Smear • Chronic ... • B12/Folate ... of Chronic Disease ... Diagnosis #Algorithm #Causes
Causes of Iron Deficiency
 • Diet: ↓ Intake, e.g. vegan, Malnutrition, Polyphenol / tannins, ↓ Vitamin
Causes of Iron Deficiency ... Drugs, H pylori, Celiac ... disease (↑ hepcidin ... #Causes #differential ... #diagnosis #anemia
Chronic Abdominal Pain Causes - Differential Diagnosis Framework

Many patients with chronic abdominal pain have had prior
Pain Causes - Differential ... have had prior evaluations ... bowel syndrome • Celiac ... #Chronic #Causes ... #Differential #
Vitamin B12 (Cobalamin) Deficiency
Etiology:
 • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation