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diagnosis hematology cobalamin algorithm classification mcv vitamin acidosis cirrhosis elevatedmcv elevation falls geriatrics hepatology lactate lactic macrocytic macrocytosis management mds
Causes of Vitamin B12 Deficiency - Cobalamin Decreased Intake Pancreas: Insufficiency Intestine: SIBO, Celiac disease, IBD, Lymphoma, Amyloidosis, Resection,
B12 Deficiency ... Intestine: SIBO, Celiac ... disease, IBD, Lymphoma ... Stomach: Pernicious anemia ... #differential #
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Volume (MCV) - Differential ... Diagnosis Algorithm Low ... (>100 fL) • B12 ... Classification #Differential
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Volume (MCV) - Differential ... • Dietary Deficiency ... - Low Serum B12 ... and Folate Deficiency
Causes of Low Vitamin B12 Levels Low vitamin B12 intake - Vegetarianism, chronic alcoholism and older people Autoimmune
Causes of Low Vitamin ... B12 Levels Low ... vitamin B12 intake ... , coeliac disease ... #differential #
Diagnostic Framework for Anemia (Morphological Approach - MCV) Low MCV - <80fL - "Microcytic" • Iron deficiency
Approach - MCV) Low ... chronic kidney disease ... Megaloblastic: Vitamin B12 ... morphologic #mcv #differential ... #diagnosis #causes
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
) Deficiency Etiology ... • Common Causes ... related to IBD, celiac ... disease, other ... total body stores Evaluation
Causes of Anemia in Cirrhosis - Differential Diagnosis Framework LOW RETIC INDEX - ↓ PRODUCTION • Vitamin
Causes of Anemia ... in Cirrhosis - Differential ... Diagnosis Framework LOW ... PRODUCTION • Vitamin B12 ... , DIC-low factor
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
TTP - Laboratory Evaluation ... hallmark for the disease ... result in severe anemia ... WBC count and differential ... ThromboticThrombocytopenicPurpura #Diagnosis #Workup
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
formed or don’t work ... Myeloproliferative Disease ... Nutritional: vitamin B12 ... Workup: • Complete ... blood count with differential
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Lactic Acidosis - Differential ... presentations and disease ... LV failure - Low ... 30mmHg) - Severe anemia ... effect - Thiamine deficiency
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