8 results
Aplastic Anemia Summary

 • Definition
 • Pathophysiology
 • DDx: AA vs Hypocellular MDS
 • Expectation
 •
Definition • Pathophysiology ... Anemia #diagnosis #oncology ... #hematololgy
Melanoma Pathogenesis

Environmental exposure (UV light) + genetic susceptibility (CDKN2A, CDK4, MC1R, BRAF, p16/ARF genes) → accumulation
genes and impair DNA ... #Pathophysiology ... #Oncology #Melanoma
Primary Biliary Cirrhosis - Pathophysiology
Environmental Risk Factors: Geographic location, Smoking, Microbial triggers, Xenobiotics, Nail polish
Epigentics Risk
Biliary Cirrhosis - Pathophysiology ... female-predominant disease), DNA ... relative with PBC Pathophysiology ... Biliary #Cirrhosis #Pathophysiology ... #hepatology
Pathophysiology of Euglycemic DKA in SGLT2 Inhibitors
 • Kidney: Glycosuria, Natriuresis, ↑ Ketone bodies reabsorption
 •
Pathophysiology ... of Euglycemic DKA ... → Euglycemic DKA ... SGLT2i #Inhibitors #pathophysiology ... #nephrology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... diagnosis #management #hematology ... #oncology
Aplastic Anemia - Overview

Who?
• M = F
• 3 peaks:	1) Childhood	2) 15-25 years	3) >60 years

What?
• Aplastic anemia
cells to repair DNA ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Retroviral Infections: Mechanisms of Oncogenesis
Note: A retrovirus is an RNA virus that uses reverse transcriptase to
to synthesize DNA ... incorporating the new DNA ... #oncogenesis #pathophysiology ... #immunology #oncology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
mutation in their DNA ... the cells have DNA ... erythropoietin) • DNA ... Syndromes #diagnosis #hematology ... #oncology