30 results
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... ) (e.g. lupus, CLL ... lymphoproliferative disorders ... #differential #diagnosis ... #hematology #anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
- Differential Diagnosis ... Consider sickle cell ... Consider RBC membrane disorder ... #Differential #Diagnosis ... Algorithm #workup #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
lymphoproliferative disorder ... lymphoid malignancy (CLL ... Diagnosis: • hemolytic ... significance (MGUS), CLL ... #hematology #diagnosis
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
- Differential Diagnosis ... Myeloproliferative disorders ... Serum Sickness Hemolytic ... Cell Disease (children ... Algorithm #Causes #Hematology
Red Blood Cell (RBC) Morphology
Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Microangiopathic Hemolytic ... Unstable hemoglobin disorders ... Cold autoimmune hemolytic ... #differential #diagnosis ... #hematology #microscopy
Summary of Coagulation Deficiencies
Inherited:
 • Hemophilia A - Deficiency of Factor VIII
 • Hemophilia B -
Summary of Coagulation ... LMWH, warfarin, DOACs ... Malignancy, Autoimmune disorders ... table #comparison #diagnosis ... #hematology #deficiency
Causes of Thrombocytosis - Differential Diagnosis
Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis):
 • Acute infection
 • Solid organ
- Differential Diagnosis ... iron deficiency, hemolysis ... Chronic inflammatory disorders ... myeloid leukemia (CML ... #Causes #hematology
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Lymphocytic Leukemia - Summary ... Physical Exam/Signs ... cells can indicate disease ... lymphoproliferative disorders ... workup #oncology #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
- Differential Diagnosis ... PT, aPTT(liver disease ... changes), high MCV ... not required in all ... Causes #Workup #hematology
Basophilia - Differential Diagnosis Framework

Basophils < 1% of the total white blood cell count
Basophils function similarly
- Differential Diagnosis ... Myeloproliferative Disorders ... myeloid leukemia (CML ... Colitis and Crohn’s Disease ... #causes #hematology