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Thrombotic Microangiopathies In Systemic Lupus Erythematosus

Dr. Laurent ARNAUD @Lupusreference

#TMAs #Thrombotic #Microangiopathies #Systemic #Lupus #Erythematosus #SLE #hematology
Erythematosus ... #Erythematosus ... #SLE #hematology ... #rheumatology # ... differential #diagnosis
ANA Patterns and Associated Rheumatic Diseases:
 • Homogeneous: Systemic lupus erythematosus (SLE), Mixed connective tissue disease
erythematosus ( ... erythematosus ( ... erythematosus ( ... #patterns #rheumatology ... #diagnosis #differential
Pancytopenia - Differential Diagnosis

Congenital Diseases:
• GATA2 deficiency
• Fanconi’s anemia
• Wiskott-Aldrich syndrome
• Ribosomopathy or telomeropathy

Cancer:
• Leukemia
• Lymphoma

Inflammatory
Diagnosis Congenital ... Inflammatory and ... Diseases: • Systemic lupus ... erythematosus ... #Diagnosis #Hematology
Systemic Lupus Erythematosus - Diagnosis
Manifestations:
 - Arthritis 69%
 - Malar rash 40%
 - Fever 36%
 -
Systemic Lupus Erythematosus ... Auto-Antibodies: - ANA ... Diagnosis and Lupus ... #signs #symptoms ... #rheumatology
An Approach to the Unknown Rash: Erythematous Rash 

#Diagnosis #Dermatology #Erythematous #Rash #Differential #Algorithm #Nikolsky #Sign
An Approach to the ... Rash #Diagnosis ... #Dermatology #Erythematous ... #Rash #Differential ... Algorithm #Nikolsky #Sign
Combination of Skin Findings and Arthritis in Pediatrics Patient - Differential Diagnosis
Malar rash: 
 • A
Pediatrics Patient - Differential ... Diagnosis Malar ... migrans: • Target sign ... gabrieltalledop #dermatology ... #diagnosis #peds
Skin Conditions Associated with Joint Pain

Rash
	• Human parvovirus B19 infection

Malar rash
	• SLE
	• Human parvovirus B19 infection
	•
lesions • Discoid lupus ... erythematosus ... Sarcoidosis #dermatology ... #skin #rashes #differential ... #diagnosis #rheumatology
Causes of Splenomegaly - Differential Diagnosis Algorithm
Infectious
 • Bacterial
 • Viral (EBV)
 • Parasitic
 • Fungal
Congestive
Splenomegaly - Differential ... Diagnosis Algorithm ... Inflammatory • Systemic Lupus ... Erythematosus ... #Causes #Hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Non-autoimmune rheumatologic ... La, anti-Jo-1, SCL ... #Diagnosis #Rheumatology
Causes of Hypocomplementemia - CHAMPS Mnemonic
C - Cryoglobulinemia (85%), C3 glomerulopathy, cirrhosis
H - Heavy Chain deposition
S - Systemic Lupus ... Erythematosus ( ... CHAMPS #Mnemonic #diagnosis ... #differential # ... hematology