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management differential rheumatology oncology acute apml behcet chronic cll complexes criteria dermatology dermatosis differentiation diuresis diuretics edema endocarditis erythematosus excretion
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
, dyspnea, +/- CXR ... lethargy, hematuria, cardiac ... with tetany or cardiac ... #TLS #diagnosis ... #management #hematology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... common • Imaging: CXR ... fluid overload, PCC ... #management #hematology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
thrombosis, VTE) • Cardiac ... ) Differential Diagnosis ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... Malignancy (e.g. hematologic ... 5% of patients Cardiac ... Cytopenias • Cardiac ... La, anti-Jo-1, SCL
Hepatopulmonary Syndrome - Diagnosis and Management Summary A defect in arterial oxygenation due to a gas exchange
Hepatopulmonary Syndrome ... left heart 3-6 cardiac ... ) on room air Treatment ... hepatopulmonary #syndrome ... #treatment #hepatology
Diuretics and Agents Regulating Renal Excretion Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide) • Glaucoma • Epilepsy • Altitude
disequilibrium syndrome ... • Diagnosis of ... Inhibitors of Na+K+2Cl ... • Bleeding • Cardiac ... Tolvaptan) • Treatment
Diagnostic Criteria for Sweet Syndrome (Acute Febrile Neutrophilic Dermatosis) Major criteria 1. Abrupt onset of tender
Diagnostic Criteria ... for Sweet Syndrome ... inflammatory disease ... Excellent response to treatment ... count >10 x 10^3/pL
Noncardiogenic Pulmonary Edema - Differential Diagnosis Framework NCPE Pathophysiology: Noncardiogenic pulmonary edema occurs because of excessive pulmonary capillary
lack of acute cardiac ... disease • Normal ... ischemic changes CXR ... respiratory distress syndrome ... #cardiology
Premature Ventricular Complexes (PVC's) - Summary Framework Why PVCs? Can be the first manifestation of cardiac
manifestation of cardiac ... Inherited arrhythmia syndromes ... (e.g., long QT syndrome ... more intensive treatment ... #differential #cardiology
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
phenomenon CLL Diagnosis ... cells can indicate disease ... microglobulin Treatment ... • Richter’s Syndrome ... workup #oncology #hematology
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