30 results
Chronic Lymphocytic Leukemia - Summary

Cancer affecting lymphocytes/Mature B cell neoplasm
 • Lymphocytes accumulate in large numbers
Diagnosis: • ... cells can indicate disease ... microglobulin Treatment ... • Richter’s Syndrome ... workup #oncology #hematology
Hemolysis - Differential Diagnosis Framework

1) Environment
  - Fragmentation
  - MAHA: TTP, HUS, DIC, HELLP
- Differential Diagnosis ... Drug-associated, PCH ... , Evans Syndrome ... Defects: Sickle cell ... #hematology
Chagas Disease (American trypanosomiasis) - Diagnosis and Management Summary
Acute Chagas Disease (8-12 weeks):
 • Mild: Malaise,
Treatment: ... PCR not useful for ... clinical evidence of cardiac ... clinical evidence of cardiac ... #Management #Microbiology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cold Agglutinin Syndrome ... malignancies -> CLL ... significance (MGUS), CLL ... Hemoglobinuria (PCH ... hemolytic #anemia #hematology
Shock - Differential Diagnosis Framework
 - MAP <65. SBP <90, drop in SBP > 40
 -
- Differential Diagnosis ... , Severe Valve Disease ... Pneumothorax, Cardiac ... Abdominal compartment syndrome ... #criticalcare #
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Lymphoma (HCV) • CLL ... • Heavy Chain disease ... Evans • ITP • Cl-NH ... Paraproteinemias #Hematology ... #Differential #Diagnosis
Behçet's Syndrome
Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy
Epidemiology:
 • Young
thrombosis, VTE) • Cardiac ... ) Differential Diagnosis ... Arthritis, AS Treatment ... #diagnosis #management ... signs #symptoms #rheumatology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Differential Diagnosis ... 5% of patients Cardiac ... Cytopenias • Cardiac ... La, anti-Jo-1, SCL ... Erythematosus #Diagnosis
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
Differentiation Syndrome ... Triggers: ATRA treatment ... • Induce blast cell ... fluid overload, PCC ... #management #hematology
Myelodysplastic Syndromes (MDS)

What?
Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myeloproliferative Disease ... factor (GCSF) treatments ... marrow studies Treatment ... Immunosuppressive treatment ... #diagnosis #hematology