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Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... not initiate if eGFR ... not continue if eGFR ... #Metformin #Pharmacology
The GFR Clock for Staging CKD Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR ... #Nephro #CKD #EGFR
Interpreting Kidney Biomarkers ↑ Creatinine: • AKI, CKD • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... hyperthyroidism ↓ eGFR
Causes of Hypomagnesemia - Differential Diagnosis Algorithm GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... Cetuximab and other EGFR ... in Na-KATPase, EGFR ... Magnesium #Low #Causes
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
45-60 Monitor eGFR ... #Dosing #Dose #Pharmacology
Adjusted Pain Medication Dosing based on GFR #Renal #Dosing #Pain #Pharmacology #Opiates #CKD #Gabapentin #Table
Dosing based on GFR ... #Dosing #Pain #Pharmacology
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
maximum dose eGFR ... recommended dose eGFR ... Metformin #CKD #pharmacology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... LiverInjury #Hepatology #Pharmacology ... #Causes #DILI
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 Summary of dosing recommendations in renal impairment of commonly used hypoglycaemic agents #Diabetes #Diabetic #Medications #Pharmacology #Dosing
#Medications #Pharmacology ... Impairment #CKD #Table #GFR
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