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Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... agent • Does not cause ... not initiate if eGFR ... not continue if eGFR ... #Metformin #Pharmacology
Causes of Hypomagnesemia - Differential Diagnosis Algorithm GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
Causes of Hypomagnesemia ... Cetuximab and other EGFR ... in Na-KATPase, EGFR ... Magnesium #Low #Causes
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
45-60 Monitor eGFR ... #Dosing #Dose #Pharmacology
Adjusted Pain Medication Dosing based on GFR #Renal #Dosing #Pain #Pharmacology #Opiates #CKD #Gabapentin #Table
Dosing based on GFR ... #Dosing #Pain #Pharmacology
Drugs and Classes Associated with DILI and Type of Liver Injury #Medications #Differential #DrugInduced #LiverInjury #Hepatology #Pharmacology
Drugs and Classes ... LiverInjury #Hepatology #Pharmacology ... #Causes #DILI
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 Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
maximum dose eGFR ... recommended dose eGFR ... Metformin #CKD #pharmacology
Summary of dosing recommendations in renal impairment of commonly used hypoglycaemic agents #Diabetes #Diabetic #Medications #Pharmacology #Dosing
#Medications #Pharmacology ... Impairment #CKD #Table #GFR
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Causes of Chronic ... kidney function (eGFR ... Sterile pyuria, WBC casts ... Diagnosis #Algorithm #Causes
Hepatorenal Syndrome (HRS) - Diagnostic Criteria HRS-AKI (Acute: previously known as HRS Type 1) • ↑ Creatinine
months - eGFR ... - No other cause ... HRS-CKD - eGFR ... - No other cause
Causes of Drug-Induced Cardiomyopathies #DrugInduced #Medications #Cardiomyopathy #Cardiomyopathies #Differential #Causes #Cardiology #Pharmacology
Causes of Drug-Induced ... #Differential #Causes ... #Cardiology #Pharmacology
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