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The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... the eGFR, CKD can ... Using the GFR clock ... to remember the eGFR
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
nephroprotective ↓ in GFR ... hyperthyroidism ↓ eGFR ... diagnosis #laboratory #nephrology
To improve the usefulness of the serum creatinine concentration as a marker of kidney function, prediction
accurately predict GFR ... overestimation of GFR ... used to estimate GFR ... #Diagnosis #Nephrology ... CockcroftGault #EGFR
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Prognosis - The eGFR ... #CKD #EGFR #Proteinuria ... Heatmap #Diagnosis #Nephrology
Regulation of GFR
Physiologically, GFR is auto-regulated very precisely with changes in the mean arterial pressure (MAP)
Regulation of GFR ... Physiologically, GFR ... Pathophysiology #Nephrology ... #GFR #FiltrationRate
Fatality / Mortality Calculations in an Outbreak
There are a number of different types of rates, risks,
Fatality / Mortality Calculations ... fatality rate (CFR ... fatality risk (HFR ... MortalityRate #Calculations ... #Outbreak #Calculating
Complications of CKD
 - Patients with stages 1-3 ([GFR] >30 mL/min) of CKD are generally asymptomatic;
with stages 1-3 ([GFR ... CKD stages 4-5 (GFR ... Pathophysiology #Nephrology
Table 1. Equations for estimated glomerular filtration rate (eGFR) in adults based on serum creatinine concentration*.
#Diagnosis
filtration rate (eGFR ... #Diagnosis #Nephrology ... CockcroftGault #EGFR ... #Equations #Calculation
Definitions of AKI, CKD, AKD
Acute Kidney Injury (AKI):
 • Increase in SCr by 2 50% within
Disease (CKD): • GFR ... • AKI, OR • GFR ... • Decrease in GFR ... Disease (NKD): • GFR ... #Definitions #nephrology
Effects of Prostaglandins and NSAIDs on the Kidney
Effects of Prostaglandins on the Kidney:
 • The vasodilatory
maintaining baseline GFR ... setting of modest GFR ... use in CKD with GFR ... avoidance with GFR ... Kidney #renal #nephrology