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diagnosis differential nephrology management algorithm causes pharmacology metabolic respiratory alkalosis diabetes pathophysiology toxicology table renal ckd classification endocrinology medications treatment
Metformin Current Renal Dose Adjustments due to Risk of Lactic Acidosis > 60 No adjustment 45-60
Metformin Current ... Risk of Lactic Acidosis ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Metformin Pharmacology Summary Mechanisms of Action: • Suppresses gluconeogenesis by the liver • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... not initiate if eGFR ... not continue if eGFR ... causing lactic acidosis ... EricsMedicalLectures/ #Metformin
Metformin in Diabetic Kidney Disease Immediate release: • Initial 500 mg or 850 mg once daily •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
The GFR Clock for Staging CKD Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR ... #Nephro #CKD #EGFR
Anion Gap Metabolic Acidosis • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar • Alcoholic Ketoacidosis ± Hyperglycemia
Gap Metabolic Acidosis ... Type B lactic acidosis ... Drugs ( Albuterol, Metformin ... Cirrhosis • Uremic Acidosis ... AnionGap #Metabolic #Acidosis
Lactic Acidosis Classification - Type A vs Type B Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type A Lactic Acidosis ... Type B Lactic Acidosis ... Renal failure, Metformin ... Linezolid #Lactic #Acidosis
Metformin Associated Lactic Acidosis (MALA) Pathophysiology of MALA - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... symptoms of metabolic acidosis ... Kat_Watson #MALA #Metformin
Management of Diabetes Mellitus in Patients With CKD 1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... per 1.73 m2 with metformin ... CKD #ADA #KDIGO #eGFR ... #Insulin #metformin
Diabetes Combination Tablets - Estimated A1c Lowering Metformin + DPP4 • Janumet (metformin + sitagliptin) •
A1c Lowering Metformin ... DPP4 • Janumet (metformin ... • Jentadueto (metformin ... • Kombiglyze (metformin ... saxagliptin) Metformin
Kussmaul Breathing in Lactic Acidosis Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Breathing in Lactic Acidosis ... severe lactic acidosis ... regularly taken metformin ... for metabolic acidosis
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