209 results
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... due to Risk of Lactic ... 45-60 Monitor eGFR ... already taking metformin ... /ambcarerx #Metformin
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... not initiate if eGFR ... not continue if eGFR ... about causing lactic ... EricsMedicalLectures/ #Metformin
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... maximum dose eGFR ... recommended dose eGFR ... < 30: Stop metformin ... annually if on metformin
Lactic Acidosis Classification - Type A vs Type B
Type A Lactic Acidosis: Sepsis, Ischemic bowel, Hemorrhagic
Lactic Acidosis ... Type B Type A Lactic ... Cardiogenic shock Type B Lactic ... Renal failure, Metformin ... transcriptases, Linezolid #Lactic
The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
The GFR Clock for ... function rate (eGFR ... calculating the eGFR ... to remember the eGFR ... #Nephro #CKD #EGFR
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Metformin Associated ... Lactic Acidosis ... Pathophysiology of MALA - Metformin ... concentrations > 5 μg/mL, metformin ... Kat_Watson #MALA #Metformin
Anion Gap Metabolic Acidosis
 • Diabetic Ketoacidosis ± Hyperglycemia ± Hyperosmolar
 • Alcoholic Ketoacidosis ± Hyperglycemia
glycol • Type B lactic ... Drugs ( Albuterol, Metformin
Lactic Acidosis - Classification and Differential Diagnosis
Type A Lactic Acidosis: Inadequate Oxygen Delivery
 • Anaerobic muscular
Lactic Acidosis ... Diagnosis Type A Lactic ... Anemia Type B Lactic ... Lactate-based dialysate, Metformin ... 0885066620982585 #Lactic
Management of Diabetes Mellitus in Patients With CKD

1. Monitor for changes in BP, serum creatinine, &
FDA recommends, metformin ... T2D, CKD, & an eGFR ... per 1.73 m2 with metformin ... CKD #ADA #KDIGO #eGFR ... #Insulin #metformin
Kussmaul Breathing in Lactic Acidosis
Acute non-cardiopulmonary dyspnoea. 70 ys, DM, vomiting and URQ abdominal pain since
Kussmaul Breathing in Lactic ... BGA: severe lactic ... regularly taken metformin