167 results
Metformin in Diabetic Kidney Disease
Immediate release:
 • Initial 500 mg or 850 mg once daily
 •
Metformin in Diabetic ... Kidney Disease ... maximum dose eGFR ... recommended dose eGFR ... deficiency Monitor kidney
Interpreting Kidney Biomarkers

↑ Creatinine: 
 • AKI, CKD
 • Medications that lead to nephroprotective ↓ in
Interpreting Kidney ... Medications that ↓ renal ... hyperthyroidism ↓ eGFR ... #Biomarkers #Kidney ... #renal #diagnosis
Metformin 
Current Renal Dose Adjustments due to Risk of Lactic Acidosis 
> 60 No adjustment 
45-60
Metformin Current ... Renal Dose Adjustments ... 45-60 Monitor eGFR ... already taking metformin ... #Renal #Dosing
The GFR Clock for Staging CKD

Staging CKD is most frequently done by calculating the estimated glomerular
function rate (eGFR ... as a proxy for kidney ... filtered in the kidney ... calculating the eGFR ... #Nephro #CKD #EGFR
Metformin Pharmacology Summary
Mechanisms of Action:
 • Suppresses gluconeogenesis by the liver
 • Increases insulin-mediated glucose utilization
Metformin Pharmacology ... Contraindications: • Chronic kidney ... not initiate if eGFR ... not continue if eGFR ... EricsMedicalLectures/ #Metformin
Causes of Chronic Kidney Disease - Differential Diagnosis Algorithm
Decreased kidney function (eGFR < 60 ml/min/1.73 m2)
Causes of Chronic Kidney ... Algorithm Decreased kidney ... function (eGFR ... 3 months Pre-Renal ... Atheroemboli • Renal
Effects of Prostaglandins and NSAIDs on the Kidney
Effects of Prostaglandins on the Kidney:
 • The vasodilatory
NSAIDs on the Kidney ... Prostaglandins on the Kidney ... importance in renal ... production of renal ... Prostaglandins #NSAIDs #Kidney
Renal Failure Prognosis - The eGFR and proteinuria offers a general prognosis as demonstrated in the
Renal Failure Prognosis ... - The eGFR and ... #CKD #EGFR #Proteinuria
To improve the usefulness of the serum creatinine concentration as a marker of kidney function, prediction
as a marker of kidney ... Modification of Diet in Renal ... unless a patient's renal ... seen in acute renal ... CockcroftGault #EGFR
Hepatorenal Syndrome (HRS) - Diagnostic Criteria
HRS-AKI (Acute: previously known as HRS Type 1)
 • ↑ Creatinine
No structural kidney ... haematuria, Normal renal ... months - eGFR ... other cause of kidney ... HRS-CKD - eGFR