37 results
Causes of Prolonged PT (INR), Prolonged PTT
 • Prolonged PT (INR), Prolonged PTT
 • Prolonged PT
PTT, Normal PT ... #INR #Differential ... #Diagnosis #Algorithm ... #Causes #Hematology ... #coagulation #disorders
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup
History:
 - Prior platelet count, family
and Platelet Disorders ... : INR/PT, aPTT(liver ... #Disorders #Differential ... #Diagnosis #Causes ... #Workup #hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm
Thrombocytopenia - Quantitative Defect
 • Decreased Production
 •
Causes of Bleeding ... Platelet Function ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Von Willebrand Disease - Most common inherited bleeding disorder 
Clinical 
 • Easy bruising 
 •
inherited bleeding disorder ... Laboratory • Normal platelet ... 2B) • Normal PT ... INR • Normal aPTT ... #Diagnosis #Hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... deficiency • Liver ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... , PT, PTT (diff ... Von Willebrand Disease ... #disorders #hematology ... #diagnosis #Aggregometry
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm
Low Mean Corpuscular Volume (<80
Causes of Anemia ... (e.g. ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Causes #Hematology
Differential Diagnosis for a Prolonged PT and aPTT
If the PT and the aPTT are both prolonged,
Differential Diagnosis ... PT and the aPTT ... • Reduced liver ... #Causes #diagnosis ... hematology #coagulation
Platelet Disorders - Differential Diagnosis Framework

Qualitative Defects:
 • Adhesion
 • Aggregation
 • Secretion

Quantitative Defects:
 • Production:
Platelet Disorders ... - Differential ... • Production: Liver ... #Disorders #Differential ... #Diagnosis #hematology
Causes of Abnormal PT and/or aPTT
Prolonged Prothrombin Time (PT)
1. Acquired deficiency of FVII
PT and/or aPTT ... Early liver disease ... #Causes #diagnosis ... #differential # ... hematology #coagulation