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algorithm bleeding bruising management oncology atlas bloodcell common elevatedmcv extravascular gap globulin hemolytic hemostasis hypogammaglobulinemia immunodeficiency immunology intravascular lymphoma macrocytic
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... intravascular coagulation ... lymphoproliferative disorders ... #differential # ... diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... • Bleeding • Hemolysis ... Renal Disease, Liver ... #MCV #Classification ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Destruction • Abnormal ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... Deficiency - Abnormal ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
, coagulation disorders ... disorders CAUSES ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
(e.g. methotrexate ... , Liver disease, ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... #diagnosis #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... IgA, IgG, IgM (CVID ... changes), high MCV anemia ... Diagnosis #Causes ... #Workup #hematology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... nodosum • Immune hemolytic ... Lymphoma Workup ... number of sites of disease ... #hematology #oncology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
disorder with hypogammaglobulinemia ... • Liver diseases ... anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
of Hemostasis - Differential ... Diagnosis Framework ... von Willebrand syndrome ... discern these causes ... #Diagnosis #Hematology
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