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algorithm leukemia morphology rbc thrombocytosis workup acidosis agglutinin approach bloodcell calculation chronic cold elevatedmcv elevation extravascular gap globulin hemolysis hodgkins
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Extravascular Causes ... . sickle cell disease ... #Hemolytic #Intravascular ... #Causes #differential ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Atlas • Microcytic - Iron-deficiency anemia, Thalassemia, Sideroblastic anemia, Lead poisoning
Red Blood Cell ( ... Malignant tumors, Acute ... #key #diagnosis ... #differential # ... hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Red Blood Cell ( ... Unstable hemoglobin disorders ... RBC #Morphology #differential ... #diagnosis #hematology ... #microscopy #atlas
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Thrombocytosis): • Acute ... malignancies • Anemia ... iron deficiency, hemolysis ... #Diagnosis #Causes ... #hematology #secondary
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
→ Refer to hematology ... : Acute blood loss ... , Acute hemolysis ... , deficiency anemia ... #hematology
Overall Approach to Anemia - Differential Diagnosis Algorithm Blood Loss • Acute Bleed - Normocytic / Normochromic
Blood Loss ... • Acute Bleed - ... Disease • Marrow ... #Classification ... #Causes #Hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
anemia - Splenomegaly ... - APLS • Acute ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Cold Agglutinin Syndrome ... Diagnosis: • hemolytic ... younger pts) Differential ... #hemolytic #anemia ... #hematology #diagnosis
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Normal Blood Smear ... • Small Bowel Disorder ... Myelodysplastic Syndromes ... #Causes #Hematology
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
Chronic kidney disease ... Index > 3: • Acute ... . sickle cell anemia ... Production #Index #hematology ... #anemia #differential
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