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management algorithm coagulation abnormal anemia blood bruising pt reactions treatment activation comparison cryofibrinogenemia dic disorders disseminated elevatedmcv hemophilia hemostasis hodgkins
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Early liver disease ... Reduced liver synthesis ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80-100 fL) • Bleeding ... (e.g. ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Causes #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... • Reduced liver ... #Prolonged #Causes ... #diagnosis #differential ... #hematology #coagulation
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Diagnosis Algorithm ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... : INR/PT, aPTT(liver ... disease), HBsAg ... #Diagnosis #Causes ... #Workup #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
) • aPTT is prolonged ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... Management #treatment #hematology
Causes of Anemia with elevated Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Normal Blood Smear •
Causes of Anemia ... Diagnosis Algorithm ... Increased Requirement (e.g ... Myelodysplastic Syndromes ... #Causes #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Thrombocytopenia • Prolonged ... DIC • Severe Liver ... Disease: - Impaired ... INR < 2.3 - APTT ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... von Willebrand syndrome ... the PT remains prolonged ... discern these causes ... #Diagnosis #Hematology
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
the spleen or liver ... translocation • Types: Classification ... Hepatosplenomegaly, cytopenias(bleeding ... #differential # ... hematology
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