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algorithm blood bruising coagulation product reactions abnormal activation anemia common cvid dic disorders disseminated hemophilia hemostasis hodgkins hypogammaglobulinemia immunodeficiency immunology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
80-100 fL) • Bleeding ... • Hemolysis ... Renal Disease, Liver ... #Anemia #MCV #Classification ... #Causes #Hematology
Causes of Bleeding / Bruising - Differential Diagnosis Algorithm Thrombocytopenia - Quantitative Defect • Decreased Production •
Causes of Bleeding ... Diagnosis Algorithm ... Rare • Drugs (e.g ... Iatrogenic) • Liver ... #Causes #Hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... : INR/PT, aPTT(liver ... disease), HBsAg ... #Diagnosis #Causes ... #Workup #hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Syndrome - Diagnosis ... thrombocythemia), Autoimmune disease ... #Diagnosis #Management ... #treatment #hematology ... #differential
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... #Management #treatment ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Acquired deficiency ... Early liver disease ... Reduced liver synthesis ... #diagnosis #differential ... #hematology #coagulation
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Diagnosis Framework ... von Willebrand syndrome ... discern these causes ... : • Liver disease ... #Diagnosis #Hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
DIC • Severe Liver ... Disease: - Impaired ... INR < 2.3 - APTT ... #causes #treatment ... #management #hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
the secondary or acquired ... purpura to mucosal bleeding ... thrombocytopenia • Liver ... #Diagnosis #Management ... #Hematology #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
• Liver diseases ... and autoimmune hemolytic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
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