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algorithm anemia extravascular focal hemolytic intravascular leukemia localized lupus lymphadenopathy mcv mds myelodysplasia myelodysplastic sle spleen splenomegaly syndromes systemic vasculitides
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Malignant • Lymphoma ... Systemic Lupus Erythematosus ... Serum Sickness Hemolytic ... Splenomegaly #Spleen #Enlarged ... #Causes #Hematology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
Diagnostic Framework ... Extravascular Causes ... . lupus, CLL, lymphoma ... #differential # ... diagnosis #hematology
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Thalassemia • Lead ... • Bleeding • Hemolysis ... Disease (e.g. ... #Anemia #MCV #Classification ... #Causes #Hematology
Causes of Localized Lymphadenopathy - Differential Diagnosis Algorithm Cervical: - Anterior • Infection
• Kikuchi Disease ... Tularemia • Secondary ... Lymphadenopathy #LAD ... #Causes #Hematology ... #Oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... . hematologic) ... with Lupus: • Chronic ... #Diagnosis #Rheumatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
extramedullary disease ... activity • ↓ LAP ... bone marrow and secondary ... #Leukemia #Hematology ... #Oncology #Diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
Eosinophilia, asthma, chronic ... tract, and often causes ... retinopathy Lab ... #diagnosis #rheumatology ... #classification
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
DDX: Rule Out Secondary ... Marrow Failure • Chronic ... Myeloproliferative Disease ... #diagnosis #hematology ... #oncology
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