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diagnosis anemia algorithm causes hemolytic management oncology atlas bloodcell calculation cold enlarged erythematosus extravascular hepatitis hodgkins index injury intravascular liver
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes Intravascular Hemolysis: • Mechanical Trauma (Microangiopathic hemolytic anemia):
. lupus, CLL, lymphoma ... . primary cold agglutin ... • Intrinsic RBC ... Extravascular #Causes #differential ... #diagnosis #hematology
Cold Agglutinin Disease 3 Types of Cold Sensitive Antibodies: 1. Cold Agglutinins (CAD) 2. Donath-Landsteiner
Syndrome (CAS): ... - Monoclonal - Lymphoid ... younger pts) Differential ... #disease #hemolytic ... #anemia #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... IgM associated lymphoma ... , Malignant lymphoma ... #Morphology #differential ... #diagnosis #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
Splenomegaly - Differential ... Malignant • Lymphoma ... Serum Sickness Hemolytic ... Spherocytosis • Acquired ... Algorithm #Causes #Hematology
Acquired von Willebrand Syndrome - Diagnosis and Management • Autoantibodies to vWF: Lymphoproliferative disorders (e.g. lymphoma,
Acquired von Willebrand ... . lymphoma, multiple ... thrombocythemia), Autoimmune disease ... Management #treatment #hematology ... #differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor The maturation factor is
transform into a RBC ... Chronic kidney disease ... • "Hospital-acquired ... Production #Index #hematology ... #anemia #differential
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Liver Injury - Differential ... vein: Budd-chiari syndrome ... cell lung CA, lymphoma ... • Gilbert's syndrome ... diagnosis #algorithm #hepatology
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
+Organomegaly+↑RBC ... angioedema • vWD • acquired ... • Coombs (-) hemolytic ... Paraproteinemias #Hematology ... #Monoclonal #Differential
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
nodosum • Immune hemolytic ... platelets - WBC ... Immunohistochemical studies (to differentiate ... number of sites of disease ... #hematology #oncology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: ... permanent alopecia Differential ... . hematologic) ... vein thrombosis Hematologic ... titers > 1:80 • CBC
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