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diagnosis differential management hepatology hepatitis injury liver abdominal alcoholic amiodarone dermatology dili distention druginduced endocrinology essential et fatigue gravis increased
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Myelofibrosis Infectious ... : • Acute or Chronic ... effect following treatment ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... ): • Acute infection ... inflammatory disorders (e.g ... Myelodysplastic syndrome ... #hematology #secondary
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm Peripheral Smear concerning for malignancy?
Differential Diagnosis Algorithm ... Rebound effect from treatment ... Kawasaki, Nephrotic syndrome ... : Chronic infections ... Differential #Diagnosis #Algorithm
Causes of Neutrophilia - Increased Neutrophils - Differential Diagnosis Algorithm Infection • Bacterial • Abscess • Viral Medications
Infection • ... Solid Tumour (e.g ... Myeloproliferative Disorder • Chronic ... Polycythemia vera Acute ... #Causes #Hematology
Short Stature - Differential Diagnosis Algorithm Normal Variant, Normal Puberty Onset (BA = CA) • Familial Short
Differential Diagnosis Algorithm ... Panhypopituitarism Treatment ... CRF) • Infection ... Chronic UTI) • ... endocrinology #causes
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Malignancy Infectious ... • Drug Abuse (e.g ... Fatigue Syndrome
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
non-essential drug/HDS treatments ... for alternative causes ... Hepatocellular: Viral infections ... dechallenge • Acute ... #hepatology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... basophilia, and thrombocytosis ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology
Myasthenia Gravis Overview Myasthenia Gravis is an autoimmune disorder of the postsynaptic neuromuscular junction. Ab to
Serologic and EMG ... inhibition - Chronic ... Myasthenia Crises ... aspiration and acute ... precipitated by: Drugs, infection
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
Differential Diagnosis Algorithm ... Vascular Causes ... vein: Budd-chiari syndrome ... Liver Injury: • Infectious ... #hepatology
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