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diagnosis rheumatology differential erythematosus hematology lupus sle allergy autoimmune classification hypersensitivity management oncology reactions symptoms table types algorithm allergic antibody
Warm Antibody Autoimmune Hemolytic Anemia 1) DIAGNOSE AIHA • Anemia: macrocytic > normocytic, ↑ reticulocytes •
Antibody Autoimmune Hemolytic ... Anemia 1) DIAGNOSE ... AIHA • Anemia ... LDH • Anti-RBC autoantibodies ... FOR a cause → Systematic
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Malar rash 40% - Fever ... Lymphadenopathies 7% - Hemolytic ... anemia 4% - Myositis ... Erythematosus #Diagnosis #autoantibodies ... #signs #symptoms
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features of Systemic ... (SLE) General: Fever ... ) Blood (75%): Anemia ... normochromic nomocytic or haemolytic ... erythematosus #signs
Pemphigus Vulgaris vs Bullous Pemphigoid - Comparison Table Pemphigus Vulgaris • Epidemiology: Average age 40-60 • Time
Bullous Pemphigoid - Comparison ... ruptured • Nikolsky sign ... • Antibodies: Autoantibodies ... • Treatment: Systemic ... Tense • Nikolsky sign
Hypersensitivity: Summary Type I Hypersensitivity: • Immunological Mediator: lgE • Immunological Target: Allergen Molecules • Ex: Antibiotic
peanuts), Hay fever ... thrombocytopenia, Autoimmune Hemolytic ... anemia, Penicillin-induced ... complexes • Ex: Systemic
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... schistosomiasis • Pyemia ... Brucellosis Faget's Sign ... with profound hemolysis
Paraproteinemias Entities That Can Feature A Monoclonal Protein/M Component: • MM • WM • MGUS • MGCS • MGRS • Splenic Marginal Zone
clubbing Clarkson/Systemic ... neuropathy) • Systemic ... macular Vasculitis) Autoantibodies ... • Coombs (-) hemolytic ... anemia due to cold
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
pathognomonic signs ... Clinical features: Fever ... -, Systemic embolism ... +, Systemic embolism ... #Endocarditis #comparison
Summary table of types of hypersensitivity reactions. Type 1 - Mediators: lgE - Antigen Form: Soluble
Anaphylaxis, Hay fever ... transfusion reaction, Haemolytic ... glomerulonephritis, Systemic ... classification #comparison
Evaluation of suspected incomplete Kawasaki Disease 1. AHA consensus recommendations 2. Infants ≤6 months old on day ≥7
old on day ≥7 of fever ... if evidence of systemic ... Albumin ≤3.0 g/dL, anemia ... within 10 d of fever ... clinical and lab signs
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