18 results
Causes of Bone/Joint Pain in Sickle Cell Disease
Vaso-occlusive pain:
 • Mechanism: ischemic pain
 • Can present
Causes of Bone/Joint ... Generally affects long bones ... • Differentiate ... #Disease #differential ... diagnosis #causes #hematology
Sickle Cell Disease - Pathophysiology of disease and complications 

Due to the deformed shape, HbS induces
Cell Disease - Pathophysiology ... to the deformed shape ... , necrosis and pain ... SickleCell #Disease #Pathophysiology ... Complications #Hematology
Anterior Shoulder Dislocation: Pathogenesis, clinical, and radiographic findings

Trauma, Fall on, outstretched arm, Overhead throwing => Abduction
on axillary x-ray ... and underlying bone ... -> Pain #Anterior ... signs #symptoms #msk ... #orthopedics #pathophysiology
Approach to Joint Pain

History:
Is the pain from:
	• Joint
	• Adjacent bursa
	• Tendon
	• Ligament
	• Bone
	• Muscle
	• Referred from
Approach to Joint Pain ... • Ligament • Bone ... the subchondral bone ... #MSK #rheumatology ... approach #workup #differential
Approach to Joint Pain - Arthritis Differential Diagnosis Framework

Inflammatory Versus Noninflammatory Pain
 • Is it inflammatory
- Arthritis Differential ... - Autoimmune Rheumatologic ... #Differential # ... Diagnosis #MSK # ... rheumatology #Monoarticular
Lymphomas and Lymphoproliferative Disorders - Differential Diagnosis Algorithm
Hodgkin Lymphoma ~40% - Characteristic For Reed-Sternberg (RS) Cells
Lymphoproliferative Disorders - Differential ... Amy Chung, MD, MSc ... Classification #pathophysiology ... #Hematology #Diagnosis ... #NonHodgkin #differential
Gout (Gouty Arthritis) - MSK Radiology
Imaging Findings:
 • Eccentric soft-tissue densities surrounding the third proximal interphalangeal
Gouty Arthritis) - MSK ... diagnosed ON THE X-RAY ... - **MSK rads ... Differential diagnosis ... #rheumatology
Causes of Knee Effusions - Differential Diagnosis Framework

Knee Effusion Red Flags:
1. Fever/Chills/Joint pain/Night sweats/Weight loss
	- DDX:
		-
Knee Effusions - Differential ... Fever/Chills/Joint pain ... Effusions: - Hematologic ... - Aneurysmal bone ... #diagnosis #msk
Polycythemia - Differential Diagnosis Algorithm
Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
Polycythemia - Differential ... check at least one ... Better call hematology ... #Polycythemia #Differential ... Algorithm #workup #hematology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... effusions, weight gain ... initiation • Differential ... diagnosis #management #hematology