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rheumatology erythematosus hematology signs sle syndrome systemic activation algorithm amiodarone apml autoantibodies autoimmune biliary causes checklist cholangitis cirrhosis classification crisis
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
Myositis 4% - Lung ... Diagnosis and Lupus ... Mimickers: Drug-induced ... autoantibodies #signs ... #symptoms #mimickers
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI) DILI Types: • Intrinsic - predictable, dose dependent
Diagnosis and Management ... ongoing ↑ LFTs or symptoms ... Idiosyncratic #differential ... #Diagnosis #Management ... gastroenterology #hepatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... Lupus: • Symptoms ... Antihistone: Drug induced ... Erythematosus #Diagnosis
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
failure PBC Signs ... and Symptoms: ... bile ducts Differential ... Sarcoidosis, Drug-induced ... #workup #hepatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
rash) • Heart, lung ... SJIA], systemic lupus ... Sepsis • Drug-induced ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Sarcoidosis - Diagnosis and Management Summary Epidemiology 1) High incidence in Scandinavian countries (11-24 cases per 100,000 individuals
Sarcoidosis - Diagnosis ... and Management ... granulomas within the lungs ... skin (16-32%): lupus ... #Management #Signs
Amiodarone Induced Lung Toxicity Summary Who? • 5% of patients • Dose ≥ 400 mg per day How? Possible
and masses, and exudative ... gradually with symptoms ... Fever 4. ... Improvement in symptoms ... #management #Toxicology
Portopulmonary Hypertension Presence of pulmonary arterial hypertension in a patient with portal hypertension No other obvious causes (chronic
causes (chronic lung ... m/s • Other signs ... oxide through reduced ... hemodynamics Liver ... #management #hepatology
Rhabdomyolysis - Differential Diagnosis Framework and Management Summary Causes of Rhabdomyolysis: • Trauma: - Immobilization - Crush injury - Compartment
Rhabdomyolysis - Differential ... Diagnosis Framework ... and Management ... : • Triad of symptoms ... #Diagnosis #Management
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
endothelial damage • Induce ... Subacute-Acute: • Common: fever ... : >3 symptoms, or ... initiation • Differential ... #management #hematology
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