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Clinical Manifestations of Human Herpes Viruses (HHV) Herpes simplex virus 1 HSV-1 Frequently subclinical (80-90%) Oral lesions (10-20%) congenital
Clinical Manifestations ... virus 7 HHV-7 Fever ... Microbiology #Diagnosis #Comparison
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
high index of clinical ... Hypercoagulable states • Clinical ... features: Fever ... features: Fever ... #Endocarditis #comparison
HHV8/KSHV-reIated diseases: From Cellular Proliferation to Hyperinflammation Kaposi sarcoma (KS): • Target organs: Ubiquitous (cutaneous and mucosal
predominance) • Clinical ... and spleen • Clinical ... features: Fever ... peritoneal cavities • Clinical ... HHV8 #diseases #comparison
Hodgkin's Lymphoma vs Non-Hodgkin's Lymphoma - Comparison Hodgkin's Lymphoma: • Epidemiology: young adults 20-30, older 50-70 •
Non-Hodgkin's Lymphoma - Comparison ... Autoimmune diseases • Clinical ... - Pel-Ebstein fever ... Noncontiguous spread • Clinical ... #NonHodgkins #comparison
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
life Causes and clinical ... symptoms - Headache, fever ... #rheumatology #comparison
Faget Sign - Pulse-Temperature Dissociation Causes of Relative Bradycardia • Infectious Causes: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
Faget's Sign & Liebermeister's Rule Pulse-Temperature Dissociation EVERY 1 F RISE IN TEMPERATURE -> HR INCREASES 8-10 BPM INFECTIOUS
Psittacosis • Q Fever ... • Typhoid Fever ... • Drug Fever ... CLINICAL UTILITY ... Typhoid Fever (S
Fever Patterns - Differential Diagnosis Framework Continuous Fever: Temp > 38°C with only 1 degree fluctuation in 24
Fever Patterns - ... Continuous Fever ... (Step ladder: fever ... Intermittent Fever ... or no fever •
CMV vs EBV - Mononucleosis Acute CMV Infection: • Asymptomatic (most common) • Infectious mononucleosis (fever/chills, malaise)
mononucleosis (fever ... , malaise) • Fever ... common EBV • Fever ... Mononucleosis #diagnosis #comparison
Causes of Relative Bradycardia - Note the propensity for intracellular organisms. Infectious: Legionella, Psittacosis, Q fever, Typhoid
Psittacosis, Q fever ... , Typhoid fever, ... , Dengue fever, ... Mountain spotted fever ... , Drug fever
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