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diagnosis differential hematology generalized pruritus systemic elevatedmcv endocrinology gout hemolytic hyperuricemia leukemia mcv microcytic nonpalpable normocytic oncology palpable purpura rheumatology
Hemolysis - Diagnostic Algorithm and Causes Increased red cell production: • Increased Reticulocytosis/polychromasia • Erythroid
Algorithm and Causes ... Urobilinogen • + urinary ... #Hemolytic #Anemia ... #Causes #Workup ... #Hematology #Diagnosis
Causes of Anemia with Normal Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased WBCs - Decreased/NormaI
Causes of Anemia ... Reticulocytosis • Primary ... Hypersplenism • Secondary ... Bleed • Hemolysis ... #Causes #Hematology
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... malignancies • Anemia ... iron deficiency, hemolysis ... Post-splenectomy Primary ... #hematology #secondary
Causes of Anemia by Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Low Mean Corpuscular Volume (<80
Causes of Anemia ... Differential Diagnosis Algorithm ... • Bleeding • Hemolysis ... #MCV #Classification ... #Causes #Hematology
Causes of Anemia with Low Mean Corpuscular Volume (MCV) - Differential Diagnosis Algorithm Decreased Heme Synthesis or
Causes of Anemia ... Differential Diagnosis Algorithm ... Secondary to Inflammation ... #Macrocytosis # ... #Causes #Hematology
Hyperuricemia - Differential Diagnosis Algorithm Primary - Over-production • Increased turnover of nucleotides Primary
Primary - Over-production ... of nucleotides Primary ... Leukemia (CML) - Hemolytic ... Anemia - Others ... endocrinology #causes
Pruritus - Generalized Differential Diagnosis Algorithm - Systemic and Primary Causes == Primary Skin Lesions == Macules /
Causes == Primary ... renal failure/uremia ... #secondary #systemic ... #generalized #dermatology ... #causes
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
leakage of RBC's secondary ... /Quantity: • Primary ... : ITP • Secondary ... DIC/TTP/HUS - Hemolytic ... anemia - Splenomegaly
Pruritus - No Primary Skin Lesion - Differential Diagnosis Algorithm Blood Glucose: • Diabetes Mellitus Liver Function Tests/Enzymes:
Pruritus - No Primary ... renal failure/uremia ... #Pruritus #secondary ... #generalized #dermatology ... #causes
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
activity • ↓ LAP ... -> AML: Blast crises ... - infiltrates (anemia ... + distinctive primary ... bone marrow and secondary
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