12 results
Monoclonal Gammopathy of Clinical Significance (MGUS) - Differential Diagnosis

Neurologic-Centered:
 (+) Systemic Features: POEMS, AL amyloid, Cryoglobulinemia
of Clinical Significance ... (MGUS) - Differential ... capillary leak syndrome ... #Significance #MGUS ... Differential #Diagnosis #hematology
Suggested algorithm for follow-up of monoclonal gammopathy of undetermined significance (MGUS)
Mayo Clinic Risk Stratification Model. CBC,
Suggested algorithm ... significance (MGUS ... ) Mayo Clinic Risk ... #MGUS #Followup ... #management #hematology
Suggested algorithm for bone marrow biopsy and skeletal imaging in patients with monoclonal gammopathy of undetermined
Suggested algorithm ... patients with monoclonal ... whom there are no clinical ... features concerning ... #management #hematology
Paraproteinemias

Entities That Can Feature A Monoclonal Protein/M Component:
• MM
• WM
• MGUS
• MGCS
• MGRS
• Splenic Marginal Zone
Can Feature A Monoclonal ... • MM • WM • MGUS ... Amyloidosis and monoclonal ... Thrombosis in vascular beds-renal ... Paraproteinemias #Hematology
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
Causes of false- ... amyloidosis Other causes ... plasmacytoma, POEMs syndrome ... #Gammopathies #MGUS ... #diagnosis #hematology
Complications of Monoclonal Gammopathy of Undetermined Significance (MGUS)
Fracture, Osteoporosis
 - Increased osteoclast activity and bone resorption
Significance (MGUS ... ) Fracture, Osteoporosis ... rituximab (in clinical ... high-risk situations #MGUS ... Complications #diagnosis #hematology
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
- Idiopathic monoclonal ... Cold Agglutinin Syndrome ... Viral Infection Clinical ... significance (MGUS ... hemolytic #anemia #hematology
Elevated Globulin - Protein Gap (Total Protein - Albumin > 4)

Work-up of an Elevated Globulin Gap:
•
Causes of Monoclonal ... Gammopathy Include: • MGUS ... changes (POEMS syndrome ... gastric tumors • Hematology ... differential #diagnosis #hematology
SAPHO Syndrome Summary

What?
SAPHO syndrome is a rare chronic inflammatory disorder of bone, joint, and skin characterized
Rheumatic pain Clinical ... Features: • Synovitis ... Rule out other causes ... #Rheumatology # ... diagnosis #management #Dermatology
Clarkson’s Disease - Capillary leak syndrome
Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Capillary leak syndrome ... Relapsing-remitting course +++ Clinical ... features: 1. ... Monoclonal gammopathy ... timeline #treatment #rheumatology