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rheumatology lupus erythematosus management oncology signs systemic algorithm hepatology testing alkaline alp anorexianervosa arthritis autoantibodies biliary causes cholangitis chronic cirrhosis
Approach to Leukocytosis - Differential Diagnosis Algorithm Features of hematologic malignancy: • Symptoms: B-symptoms, bruising/bleeding, fatigue/weakness, immunosuppression
Diagnosis Algorithm ... Features of ... : • Symptoms: ... B-symptoms, bruising ... hepatomegaly • Labs: anemia
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
Diagnosis and Workup ... pylori test (GI symptoms ... test, ANA (e.g., SLE ... changes), high MCV anemia ... #Workup #hematology
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Clinical Features ... Systemic Lupus (SLE ... ) Blood (75%): Anemia ... erythematosus #signs #symptoms ... #diagnosis #rheumatology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... - Differential ... Diagnosis Algorithm ... genotypes): SS, SC, SE ... #workup #hematology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - Hemolytic anemia ... Associated - SLE ... #Diagnosis #hematology
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
- Hemolytic anemia ... involvement 3% SLE-Related ... Lupusreference #SLE ... autoantibodies #signs #symptoms ... #rheumatology
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
Constitutional symptoms ... • Immunologic Workup ... #comparison #table ... #rheumatology # ... diagnosis #management
Low Alkaline Phosphatase - Hypophosphatasia Is Low Alkaline Phosphatase Of Clinical Importance? ALP enzyme- Discovered in 1923 Low
• recurrent fractures ... • Pernicious anemia ... collection with EDTA Pathophysiology ... mineralization Symptoms ... pain - Frequent fractures
Non-Infective Endocarditis (NBTE / Marantic Endocarditis) Non-infective endocarditis is also known as: Non-bacterial thrombotic endocarditis (NBTE), Aseptic
patients with SLE ... absent How can we differentiate ... pathognomonic signs/symptoms ... or echo features ... #pathophysiology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... Diagnosis: • ANCA-associated ... lymphopenia, low PLT • Anemia ... Induced Lupus: • Symptoms ... Erythematosus #Diagnosis
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